Vacuolar protein sorting-associated protein 33B (hVPS33B)
1_MAFPH 6_ RPDAP 11_ ELPDF 16_ SMLKR 21_ LARDQ 26_ LIYLL 31_ EQLPG 36_ KKDLF 41_ IEADL 46_ MSPLD 51_ RIANV 56_ SILKQ 61_ HEVDK 66_ LYKVE 71_ NKPAL 76_ SSNEQ 81_ LCFLV 86_ RPRIK 91_ NMRYI 96_ ASLVN 101_ ADKLA 106_ GRTRK 111_ YKVIF 116_ SPQKF 121_ YACEM 126_ VLEEE 131_ GIYGD 136_ VSCDE 141_ WAFSL 146_ LPLDV 151_ DLLSM 156_ ELPEF 161_ FRDYF 166_ LEGDQ 171_ RWINT 176_ VAQAL 181_ HLLST 186_ LYGPF 191_ PNCYG 196_ IGRCA 201_ KMAYE 206_ LWRNL 211_ EEEED 216_ GETKG 221_ RRPEI 226_ GHIFL 231_ LDRDV 236_ DFVTA 241_ LCSQV 246_ VYEGL 251_ VDDTF 256_ RIKCG 261_ SVDFG 266_ PEVTS 271_ SDKSL 276_ KVLLN 281_ AEDKV 286_ FNEIR 291_ NEHFS 296_ NVFGF 301_ LSQKA 306_ RNLQA 311_ QYDRR 316_ RGMDI 321_ KQMKN 326_ FVSQE 331_ LKGLK 336_ QEHRL 341_ LSLHI 346_ GACES 351_ IMKKK 356_ TKQDF 361_ QELIK 366_ TEHAL 371_ LEGFN 376_ IREST 381_ SYIEE 386_ HIDRQ 391_ VSPIE 396_ SLRLM 401_ CLLSI 406_ TENGL 411_ IPKDY 416_ RSLKT 421_ QYLQS 426_ YGPEH 431_ LLTFS 436_ NLRRA 441_ GLLTE 446_ QAPGD 451_ TLTAV 456_ ESKVS 461_ KLVTD 466_ KAAGK 471_ ITDAF 476_ SSLAK 481_ RSNFR 486_ AISKK 491_ LNLIP 496_ RVDGE 501_ YDLKV 506_ PRDMA 511_ YVFGG 516_ AYVPL 521_ SCRII 526_ EQVLE 531_ RRSWQ 536_ GLDEV 541_ VRLLN 546_ CSDFA 551_ FTDMT 556_ KEDKA 561_ SSESL 566_ RLILV 571_ VFLGG 576_ CTFSE 581_ ISALR 586_ FLGRE 591_ KGYRF 596_ IFLTT 601_ AVTNS 606_ ARLME 611_AMSEV
1: May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Required for proper trafficking and targeting of the collagen-modifying enzyme lysyl hydroxylase 3 (LH3) to intracellular collagen (PubMed:28017832). Mediates phagolysosomal fusion in macrophages (PubMed:18474358). Proposed to be involved in endosomal maturation implicating VIPAS39. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical recycling pathway and in the maintenance of the apical-basolateral polarity (PubMed:20190753). Seems to be involved in the sorting of specific cargos from the trans-Golgi network to alpha-granule-destined multivesicular bodies (MVBs) promoting MVBs maturation in megakaryocytes (By similarity)