Vacuolar protein sorting-associated protein 16 homolog (hVPS16)
1_MDCYT 6_ ANWNP 11_ LGDSA 16_ FYRKY 21_ ELYSM 26_ DWDLK 31_ EELRD 36_ CLVAA 41_ APYGG 46_ PIALL 51_ RNPWR 56_ KEKAA 61_ SVRPV 66_ LDIYS 71_ ASGMP 76_ LASLL 81_ WKSGP 86_ VVSLG 91_ WSAEE 96_ ELLCV 101_ QEDGA 106_ VLVYG 111_ LHGDF 116_ RRHFS 121_ MGNEV 126_ LQNRV 131_ LDARI 136_ FHTEF 141_ GSGVA 146_ ILTGA 151_ HRFTL 156_ SANVG 161_ DLKLR 166_ RMPEV 171_ PGLQS 176_ APSCW 181_ TVLCQ 186_ DRVAH 191_ ILLAV 196_ GPDLY 201_ LLDHA 206_ ACSAV 211_ TPPGL 216_ APGVS 221_ SFLQM 226_ AVSFT 231_ YRHLA 236_ LFTDT 241_ GYIWM 246_ GTASL 251_ KEKLC 256_ EFNCN 261_ IRAPP 266_ KQMVW 271_ CSRPR 276_ SKERA 281_ VVVAW 286_ ERRLM 291_ VVGDA 296_ PESIQ 301_ FVLDE 306_ DSYLV 311_ PELDG 316_ VRIFS 321_ RSTHE 326_ FLHEV 331_ PAASE 336_ EIFKI 341_ ASMAP 346_ GALLL 351_ EAQKE 356_ YEKES 361_ QKADE 366_ YLREI 371_ QELGQ 376_ LTQAV 381_ QQCIE 386_ AAGHE 391_ HQPDM 396_ QKSLL 401_ RAASF 406_ GKCFL 411_ DRFPP 416_ DSFVH 421_ MCQDL 426_ RVLNA 431_ VRDYH 436_ IGIPL 441_ TYSQY 446_ KQLTI 451_ QVLLD 456_ RLVLR 461_ RLYPL 466_ AIQIC 471_ EYLRL 476_ PEVQG 481_ VSRIL 486_ AHWAC 491_ YKVQQ 496_ KDVSD 501_ EDVAR 506_ AINQK 511_ LGDTP 516_ GVSYS 521_ DIAAR 526_ AYGCG 531_ RTELA 536_ IKLLE 541_ YEPRS 546_ GEQVP 551_ LLLKM 556_ KRSKL 561_ ALSKA 566_ IESGD 571_ TDLVF 576_ TVLLH 581_ LKNEL 586_ NRGDF 591_ FMTLR 596_ NQPMA 601_ LSLYR 606_ QFCKH 611_ QELET 616_ LKDLY 621_ NQDDN 626_ HQELG 631_ SFHIR 636_ ASYAA 641_ EERIE 646_ GRVAA 651_ LQTAA 656_ DAFYK 661_ AKNEF 666_ AAKAT 671_ EDQMR 676_ LLRLQ 681_ RRLED 686_ ELGGQ 691_ FLDLS 696_ LHDTV 701_ TTLIL 706_ GGHNK 711_ RAEQL 716_ ARDFR 721_ IPDKR 726_ LWWLK 731_ LTALA 736_ DLEDW 741_ EELEK 746_ FSKSK 751_ KSPIG 756_ YLPFV 761_ EICMK 766_ QHNKY 771_ EAKKY 776_ ASRVG 781_ PEQKV 786_ KALLL 791_ VGDVA 796_ QAADV 801_ AIEHR 806_ NEAEL 811_ SLVLS 816_ HCTGA 821_ TDGAT 826_ ADKIQ 831_RARAQ
1: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for recruitment of VPS33A to the HOPS complex (PubMed:23901104). Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with VPS33A but not VPS33B (PubMed:25783203). The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG (PubMed:24554770)