Vacuolar protein sorting-associated protein 11 homolog (hVPS11) (RING finger protein 108)
1_MAAYL 6_ QWRRF 11_ VFFDK 16_ ELVKE 21_ PLSND 26_ GAAPG 31_ ATPAS 36_ GSAAS 41_ KFLCL 46_ PPGIT 51_ VCDSG 56_ RGSLV 61_ FGDME 66_ GQIWF 71_ LPRSL 76_ QLTGF 81_ QAYKL 86_ RVTHL 91_ YQLKQ 96_ HNILA 101_ SVGED 106_ EEGIN 111_ PLVKI 116_ WNLEK 121_ RDGGN 126_ PLCTR 131_ IFPAI 136_ PGTEP 141_ TVVSC 146_ LTVHE 151_ NLNFM 156_ AIGFT 161_ DGSVT 166_ LNKGD 171_ ITRDR 176_ HSKTQ 181_ ILHKG 186_ NYPVT 191_ GLAFR 196_ QAGKT 201_ THLFV 206_ VTTEN 211_ VQSYI 216_ VSGKD 221_ YPRVE 226_ LDTHG 231_ CGLRC 236_ SALSD 241_ PSQDL 246_ QFIVA 251_ GDECV 256_ YLYQP 261_ DERGP 266_ CFAFE 271_ GHKLI 276_ AHWFR 281_ GYLII 286_ VSRDR 291_ KVSPK 296_ SEFTS 301_ RDSQS 306_ SDKQI 311_ LNIYD 316_ LCNKF 321_ IAYST 326_ VFEDV 331_ VDVLA 336_ EWGSL 341_ YVLTR 346_ DGRVH 351_ ALQEK 356_ DTQTK 361_ LEMLF 366_ KKNLF 371_ EMAIN 376_ LAKSQ 381_ HLDSD 386_ GLAQI 391_ FMQYG 396_ DHLYS 401_ KGNHD 406_ GAVQQ 411_ YIRTI 416_ GKLEP 421_ SYVIR 426_ KFLDA 431_ QRIHN 436_ LTAYL 441_ QTLHR 446_ QSLAN 451_ ADHTT 456_ LLLNC 461_ YTKLK 466_ DSSKL 471_ EEFIK 476_ KKSES 481_ EVHFD 486_ VETAI 491_ KVLRQ 496_ AGYYS 501_ HALYL 506_ AENHA 511_ HHEWY 516_ LKIQL 521_ EDIKN 526_ YQEAL 531_ RYIGK 536_ LPFEQ 541_ AESNM 546_ KRYGK 551_ ILMHH 556_ IPEQT 561_ TQLLK 566_ GLCTD 571_ YRPSL 576_ EGRSD 581_ REAPG 586_ CRANS 591_ EEFIP 596_ IFANN 601_ PRELK 606_ AFLEH 611_ MSEVQ 616_ PDSPQ 621_ GIYDT 626_ LLELR 631_ LQNWA 636_ HEKDP 641_ QVKEK 646_ LHAEA 651_ ISLLK 656_ SGRFC 661_ DVFDK 666_ ALVLC 671_ QMHDF 676_ QDGVL 681_ YLYEQ 686_ GKLFQ 691_ QIMHY 696_ HMQHE 701_ QYRQV 706_ ISVCE 711_ RHGEQ 716_ DPSLW 721_ EQALS 726_ YFARK 731_ EEDCK 736_ EYVAA 741_ VLKHI 746_ ENKNL 751_ MPPLL 756_ VVQTL 761_ AHNST 766_ ATLSV 771_ IRDYL 776_ VQKLQ 781_ KQSQQ 786_ IAQDE 791_ LRVRR 796_ YREET 801_ TRIRQ 806_ EIQEL 811_ KASPK 816_ IFQKT 821_ KCSIC 826_ NSALE 831_ LPSVH 836_ FLCGH 841_ SFHQH 846_ CFESY 851_ SESDA 856_ DCPTC 861_ LPENR 866_ KVMDM 871_ IRAQE 876_ QKRDL 881_ HDQFQ 886_ HQLRC 891_ SNDSF 896_ SVIAD 901_ YFGRG 906_ VFNKL 911_ TLLTD 916_ PPTAR 921_ LTSSL 926_ EAGLQ 931_ RDLLM 936_HSRRG
1: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes (PubMed:21148287). Involved in the retrograde Shiga toxin transport (PubMed:23593995)