Dendritic cell-specific transmembrane protein (DC-STAMP) (hDC-STAMP) (Dendrocyte-expressed seven transmembrane protein) (IL-four-induced protein) (FIND) (Transmembrane 7 superfamily member 4)
1_MGIWT 6_ SGTDI 11_ FLSLW 16_ EIYVS 21_ PRSPG 26_ WMDFI 31_ QHLGV 36_ CCLVA 41_ LISVG 46_ LLSVA 51_ ACWFL 56_ PSIIA 61_ AAASW 66_ IITCV 71_ LLCCS 76_ KHARC 81_ FILLV 86_ FLSCG 91_ LREGR 96_ NALIA 101_ AGTGI 106_ VILGH 111_ VENIF 116_ HNFKG 121_ LLDGM 126_ TCNLR 131_ AKSFS 136_ IHFPL 141_ LKKYI 146_ EAIQW 151_ IYGLA 156_ TPLSV 161_ FDDLV 166_ SWNQT 171_ LAVSL 176_ FSPSH 181_ VLEAQ 186_ LNDSK 191_ GEVLS 196_ VLYQM 201_ ATTTE 206_ VLSSL 211_ GQKLL 216_ AFAGL 221_ SLVLL 226_ GTGLF 231_ MKRFL 236_ GPCGW 241_ KYENI 246_ YITRQ 251_ FVQFD 256_ ERERH 261_ QQRPC 266_ VLPLN 271_ KEERR 276_ KYVII 281_ PTFWP 286_ TPKER 291_ KNLGL 296_ FFLPI 301_ LIHLC 306_ IWVLF 311_ AAVDY 316_ LLYRL 321_ IFSVS 326_ KQFQS 331_ LPGFE 336_ VHLKL 341_ HGEKQ 346_ GTQDI 351_ IHDSS 356_ FNISV 361_ FEPNC 366_ IPKPK 371_ FLLSE 376_ TWVPL 381_ SVILL 386_ ILVML 391_ GLLSS 396_ ILMQL 401_ KILVS 406_ ASFYP 411_ SVERK 416_ RIQYL 421_ HAKLL 426_ KKRSK 431_ QPLGE 436_ VKRRL 441_ SLYLT 446_ KIHFW 451_ LPVLK 456_ MIRKK 461_QMDMA
1: Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. Inhibits the development of neutrophilic granulocytes. Plays also a role in the regulation of dendritic cell (DC) antigen presentation activity by controlling phagocytic activity. Involved in the maintenance of immune self-tolerance and avoidance of autoimmune reactions