Carbohydrate sulfotransferase 8 (EC 2.8.2.-) (GalNAc-4-O-sulfotransferase 1) (GalNAc-4-ST1) (GalNAc4ST-1) (N-acetylgalactosamine-4-O-sulfotransferase 1)
1_MTLRP 6_ GTMRL 11_ ACMFS 16_ SILLF 21_ GAAGL 26_ LLFIS 31_ LQDPT 36_ ELAPQ 41_ QVPGI 46_ KFNIR 51_ PRQPH 56_ HDLPP 61_ GGSQD 66_ GDLKE 71_ PTERV 76_ TRDLS 81_ SGAPR 86_ GRNLP 91_ APDQP 96_ QPPLQ 101_ RGTRL 106_ RLRQR 111_ RRRLL 116_ IKKMP 121_ AAATI 126_ PANSS 131_ DAPFI 136_ RPGPG 141_ TLDGR 146_ WVSLH 151_ RSQQE 156_ RKRVM 161_ QEACA 166_ KYRAS 171_ SSRRA 176_ VTPRH 181_ VSRIF 186_ VEDRH 191_ RVLYC 196_ EVPKA 201_ GCSNW 206_ KRVLM 211_ VLAGL 216_ ASSTA 221_ DIQHN 226_ TVHYG 231_ SALKR 236_ LDTFD 241_ RQGIL 246_ HRLST 251_ YTKML 256_ FVREP 261_ FERLV 266_ SAFRD 271_ KFEHP 276_ NSYYH 281_ PVFGK 286_ AILAR 291_ YRANA 296_ SREAL 301_ RTGSG 306_ VRFPE 311_ FVQYL 316_ LDVHR 321_ PVGMD 326_ IHWDH 331_ VSRLC 336_ SPCLI 341_ DYDFV 346_ GKFES 351_ MEDDA 356_ NFFLS 361_ LIRAP 366_ RNLTF 371_ PRFKD 376_ RHSQE 381_ ARTTA 386_ RIAHQ 391_ YFAQL 396_ SALQR 401_ QRTYD 406_ FYYMD 411_ YLMFN 416_YSKPF
1: Catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Only active against terminal GalNAcbeta1,GalNAcbeta. Not active toward chondroitin