Gigaxonin (Kelch-like protein 16)
1_MAEGS 6_ AVSDP 11_ QHAAR 16_ LLRAL 21_ SSFRE 26_ ESRFC 31_ DAHLV 36_ LDGEE 41_ IPVQK 46_ NILAA 51_ ASPYI 56_ RTKLN 61_ YNPPK 66_ DDGST 71_ YKIEL 76_ EGISV 81_ MVMRE 86_ ILDYI 91_ FSGQI 96_ RLNED 101_ TIQDV 106_ VQAAD 111_ LLLLT 116_ DLKTL 121_ CCEFL 126_ EGCIA 131_ AENCI 136_ GIRDF 141_ ALHYC 146_ LHHVH 151_ YLATE 156_ YLETH 161_ FRDVS 166_ STEEF 171_ LELSP 176_ QKLKE 181_ VISLE 186_ KLNVG 191_ NERYV 196_ FEAVI 201_ RWIAH 206_ DTEIR 211_ KVHMK 216_ DVMSA 221_ LWVSG 226_ LDSSY 231_ LREQM 236_ LNEPL 241_ VREIV 246_ KECSN 251_ IPLSQ 256_ PQQGE 261_ AMLAN 266_ FKPRG 271_ YSECI 276_ VTVGG 281_ EERVS 286_ RKPTA 291_ AMRCM 296_ CPLYD 301_ PNRQL 306_ WIELA 311_ PLSMP 316_ RINHG 321_ VLSAE 326_ GFLFV 331_ FGGQD 336_ ENKQT 341_ LSSGE 346_ KYDPD 351_ ANTWT 356_ ALPPM 361_ NEARH 366_ NFGIV 371_ EIDGM 376_ LYILG 381_ GEDGE 386_ KELIS 391_ MECYD 396_ IYSKT 401_ WTKQP 406_ DLTMV 411_ RKIGC 416_ YAAMK 421_ KKIYA 426_ MGGGS 431_ YGKLF 436_ ESVEC 441_ YDPRT 446_ QQWTA 451_ ICPLK 456_ ERRFG 461_ AVACG 466_ VAMEL 471_ YVFGG 476_ VRSRE 481_ DAQGS 486_ EMVTC 491_ KSEFY 496_ HDEFK 501_ RWIYL 506_ NDQNL 511_ CIPAS 516_ SSFVY 521_ GAVPI 526_ GASIY 531_ VIGDL 536_ DTGTN 541_ YDYVR 546_ EFKRS 551_ TGTWH 556_ HTKPL 561_ LPSDL 566_ RRTGC 571_ AALRI 576_ ANCKL 581_ FRLQL 586_ QQGLF 591_RIRVH
1: Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of TBCB. Controls degradation of MAP1B and MAP1S, and is critical for neuronal maintenance and survival