3 beta-hydroxysteroid dehydrogenase type 7 (3 beta-hydroxysteroid dehydrogenase type VII) (3-beta-HSD VII) (3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase) (C(27) 3-beta-HSD) (EC 1.1.1.-) (Cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase) (EC 1.1.1.181)
1_MADSA 6_ QAQKL 11_ VYLVT 16_ GGCGF 21_ LGEHV 26_ VRMLL 31_ QREPR 36_ LGELR 41_ VFDQH 46_ LGPWL 51_ EELKT 56_ GPVRV 61_ TAIQG 66_ DVTQA 71_ HEVAA 76_ AVAGA 81_ HVVIH 86_ TAGLV 91_ DVFGR 96_ ASPKT 101_ IHEVN 106_ VQGTR 111_ NVIEA 116_ CVQTG 121_ TRFLV 126_ YTSSM 131_ EVVGP 136_ NTKGH 141_ PFYRG 146_ NEDTP 151_ YEAVH 156_ RHPYP 161_ CSKAL 166_ AEWLV 171_ LEANG 176_ RKVRG 181_ GLPLV 186_ TCALR 191_ PTGIY 196_ GEGHQ 201_ IMRDF 206_ YRQGL 211_ RLGGW 216_ LFRAI 221_ PASVE 226_ HGRVY 231_ VGNVA 236_ WMHVL 241_ AAREL 246_ EQRAT 251_ LMGGQ 256_ VYFCY 261_ DGSPY 266_ RSYED 271_ FNMEF 276_ LGPCG 281_ LRLVG 286_ ARPLL 291_ PYWLL 296_ VFLAA 301_ LNALL 306_ QWLLR 311_ PLVLY 316_ APLLN 321_ PYTLA 326_ VANTT 331_ FTVST 336_ DKAQR 341_ HFGYE 346_ PLFSW 351_ EDSRT 356_ RTILW 361_VQAAT
1: The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis (PubMed:11067870). Plays a key role in cell positioning and movement in lymphoid tissues by mediating degradation of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC): 7-alpha,25-OHC acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells (By similarity)