Phosducin-like protein 3 (HTPHLP) (PhPL3) (Viral IAP-associated factor 1) (VIAF-1)
1_MQDPN 6_ ADTEW 11_ NDILR 16_ KKGIL 21_ PPKES 26_ LKELE 31_ EEAEE 36_ EQRIL 41_ QQSVV 46_ KTYED 51_ MTLEE 56_ LEDHE 61_ DEFNE 66_ EDERA 71_ IEMYR 76_ RRRLA 81_ EWKAT 86_ KLKNK 91_ FGEVL 96_ EISGK 101_ DYVQE 106_ VTKAG 111_ EGLWV 116_ ILHLY 121_ KQGIP 126_ LCALI 131_ NQHLS 136_ GLARK 141_ FPDVK 146_ FIKAI 151_ STTCI 156_ PNYPD 161_ RNLPT 166_ IFVYL 171_ EGDIK 176_ AQFIG 181_ PLVFG 186_ GMNLT 191_ RDELE 196_ WKLSE 201_ SGAIM 206_ TDLEE 211_ NPKKP 216_ IEDVL 221_ LSSVR 226_ RSVLM 231_KRDSD
1: Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation (PubMed:23792958, PubMed:26059764). Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (PubMed:17429077). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (PubMed:15371430)