Poly [ADP-ribose] polymerase tankyrase-2 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 6) (ARTD6) (Poly [ADP-ribose] polymerase 5B) (Protein poly-ADP-ribosyltransferase tankyrase-2) (EC 2.4.2.-) (TNKS-2) (TRF1-interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase II) (Tankyrase-2) (TANK2) (Tankyrase-like protein) (Tankyrase-related protein)
1_MSGRR 6_ CAGGG 11_ AACAS 16_ AAAEA 21_ VEPAA 26_ RELFE 31_ ACRNG 36_ DVERV 41_ KRLVT 46_ PEKVN 51_ SRDTA 56_ GRKST 61_ PLHFA 66_ AGFGR 71_ KDVVE 76_ YLLQN 81_ GANVQ 86_ ARDDG 91_ GLIPL 96_ HNACS 101_ FGHAE 106_ VVNLL 111_ LRHGA 116_ DPNAR 121_ DNWNY 126_ TPLHE 131_ AAIKG 136_ KIDVC 141_ IVLLQ 146_ HGAEP 151_ TIRNT 156_ DGRTA 161_ LDLAD 166_ PSAKA 171_ VLTGE 176_ YKKDE 181_ LLESA 186_ RSGNE 191_ EKMMA 196_ LLTPL 201_ NVNCH 206_ ASDGR 211_ KSTPL 216_ HLAAG 221_ YNRVK 226_ IVQLL 231_ LQHGA 236_ DVHAK 241_ DKGDL 246_ VPLHN 251_ ACSYG 256_ HYEVT 261_ ELLVK 266_ HGACV 271_ NAMDL 276_ WQFTP 281_ LHEAA 286_ SKNRV 291_ EVCSL 296_ LLSYG 301_ ADPTL 306_ LNCHN 311_ KSAID 316_ LAPTP 321_ QLKER 326_ LAYEF 331_ KGHSL 336_ LQAAR 341_ EADVT 346_ RIKKH 351_ LSLEM 356_ VNFKH 361_ PQTHE 366_ TALHC 371_ AAASP 376_ YPKRK 381_ QICEL 386_ LLRKG 391_ ANINE 396_ KTKEF 401_ LTPLH 406_ VASEK 411_ AHNDV 416_ VEVVV 421_ KHEAK 426_ VNALD 431_ NLGQT 436_ SLHRA 441_ AYCGH 446_ LQTCR 451_ LLLSY 456_ GCDPN 461_ IISLQ 466_ GFTAL 471_ QMGNE 476_ NVQQL 481_ LQEGI 486_ SLGNS 491_ EADRQ 496_ LLEAA 501_ KAGDV 506_ ETVKK 511_ LCTVQ 516_ SVNCR 521_ DIEGR 526_ QSTPL 531_ HFAAG 536_ YNRVS 541_ VVEYL 546_ LQHGA 551_ DVHAK 556_ DKGGL 561_ VPLHN 566_ ACSYG 571_ HYEVA 576_ ELLVK 581_ HGAVV 586_ NVADL 591_ WKFTP 596_ LHEAA 601_ AKGKY 606_ EICKL 611_ LLQHG 616_ ADPTK 621_ KNRDG 626_ NTPLD 631_ LVKDG 636_ DTDIQ 641_ DLLRG 646_ DAALL 651_ DAAKK 656_ GCLAR 661_ VKKLS 666_ SPDNV 671_ NCRDT 676_ QGRHS 681_ TPLHL 686_ AAGYN 691_ NLEVA 696_ EYLLQ 701_ HGADV 706_ NAQDK 711_ GGLIP 716_ LHNAA 721_ SYGHV 726_ DVAAL 731_ LIKYN 736_ ACVNA 741_ TDKWA 746_ FTPLH 751_ EAAQK 756_ GRTQL 761_ CALLL 766_ AHGAD 771_ PTLKN 776_ QEGQT 781_ PLDLV 786_ SADDV 791_ SALLT 796_ AAMPP 801_ SALPS 806_ CYKPQ 811_ VLNGV 816_ RSPGA 821_ TADAL 826_ SSGPS 831_ SPSSL 836_ SAASS 841_ LDNLS 846_ GSFSE 851_ LSSVV 856_ SSSGT 861_ EGASS 866_ LEKKE 871_ VPGVD 876_ FSITQ 881_ FVRNL 886_ GLEHL 891_ MDIFE 896_ REQIT 901_ LDVLV 906_ EMGHK 911_ ELKEI 916_ GINAY 921_ GHRHK 926_ LIKGV 931_ ERLIS 936_ GQQGL 941_ NPYLT 946_ LNTSG 951_ SGTIL 956_ IDLSP 961_ DDKEF 966_ QSVEE 971_ EMQST 976_ VREHR 981_ DGGHA 986_ GGIFN 991_ RYNIL 996_ KIQKV 1001_ CNKKL 1006_ WERYT 1011_ HRRKE 1016_ VSEEN 1021_ HNHAN 1026_ ERMLF 1031_ HGSPF 1036_ VNAII 1041_ HKGFD 1046_ ERHAY 1051_ IGGMF 1056_ GAGIY 1061_ FAENS 1066_ SKSNQ 1071_ YVYGI 1076_ GGGTG 1081_ CPVHK 1086_ DRSCY 1091_ ICHRQ 1096_ LLFCR 1101_ VTLGK 1106_ SFLQF 1111_ SAMKM 1116_ AHSPP 1121_ GHHSV 1126_ TGRPS 1131_ VNGLA 1136_ LAEYV 1141_ IYRGE 1146_ QAYPE 1151_ YLITY 1156_ QIMRP 1161_EGMVD
1: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:11739745, PubMed:11802774, PubMed:19759537, PubMed:21478859, PubMed:23622245, PubMed:25043379). Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation (PubMed:19759537, PubMed:21478859). Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination (PubMed:21478859). Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length (PubMed:11739745). Stimulates 26S proteasome activity (PubMed:23622245)