Rab3 GTPase-activating protein non-catalytic subunit (RGAP-iso) (Rab3 GTPase-activating protein 150 kDa subunit) (Rab3-GAP p150) (Rab3-GAP150) (Rab3-GAP regulatory subunit)
1_MACSI 6_ VQFCY 11_ FQDLQ 16_ AARDF 21_ LFPHL 26_ REEIL 31_ SGALR 36_ RDPSK 41_ STDWE 46_ DDGWG 51_ AWEEN 56_ EPQEP 61_ EEEGN 66_ TCKTQ 71_ KTSWL 76_ QDCVL 81_ SLSPT 86_ NDLMV 91_ IAREQ 96_ KAVFL 101_ VPKWK 106_ YSDKG 111_ KEEMQ 116_ FAVGW 121_ SGSLN 126_ VEEGE 131_ CVTSA 136_ LCIPL 141_ ASQKR 146_ SSTGR 151_ PDWTC 156_ IVVGF 161_ TSGYV 166_ RFYTE 171_ NGVLL 176_ LAQLL 181_ NEDPV 186_ LQLKC 191_ RTYEI 196_ PRHPG 201_ VTEQN 206_ EELSI 211_ LYPAA 216_ IVTID 221_ GFSLF 226_ QSLRA 231_ CRNQV 236_ AKAAA 241_ SGNEN 246_ IQPPP 251_ LAYKK 256_ WGLQD 261_ IDTII 266_ DHASV 271_ GIMTL 276_ SPFDQ 281_ MKTAS 286_ NIGGF 291_ NAAIK 296_ NSPPA 301_ MSQYI 306_ TVGSN 311_ PFTGF 316_ FYALE 321_ GSTQP 326_ LLSHV 331_ ALAVA 336_ SKLTS 341_ ALFNA 346_ ASGWL 351_ GWKSK 356_ HEEEA 361_ VQKQK 366_ PKVEP 371_ ATPLA 376_ VRFGL 381_ PDSRR 386_ HGESI 391_ CLSPC 396_ NTLAA 401_ VTDDF 406_ GRVIL 411_ LDVAR 416_ GIAIR 421_ MWKGY 426_ RDAQI 431_ GWIQT 436_ VEDLH 441_ ERVPE 446_ KADFS 451_ PFGNS 456_ QGPSR 461_ VAQFL 466_ VIYAP 471_ RRGIL 476_ EVWST 481_ QQGPR 486_ VGAFN 491_ VGKHC 496_ RLLYP 501_ GYKIM 506_ GLNNV 511_ TSQSW 516_ QPQTY 521_ QICLV 526_ DPVSG 531_ SVKTV 536_ NVPFH 541_ LALSD 546_ KKSER 551_ AKDMH 556_ LVKKL 561_ AALLK 566_ TKSPN 571_ LDLVE 576_ TEIKE 581_ LILDI 586_ KYPAT 591_ KKQAL 596_ ESILA 601_ SERLP 606_ FSCLR 611_ NITQT 616_ LMDTL 621_ KSQEL 626_ ESVDE 631_ GLLQF 636_ CANKL 641_ KLLQL 646_ YESVS 651_ QLNSL 656_ DFHLD 661_ TPFSD 666_ NDLAL 671_ LLRLD 676_ EKELL 681_ KLQAL 686_ LEKYK 691_ QENTR 696_ TNVRF 701_ SDDKD 706_ GVLPV 711_ KTFLE 716_ YLEYE 721_ KDVLN 726_ IKKIS 731_ EEEYV 736_ ALGSF 741_ FFWKC 746_ LHGES 751_ STEDM 756_ CHTLE 761_ SAGLS 766_ PQLLL 771_ SLLLS 776_ VWLSK 781_ EKDIL 786_ DKPQS 791_ ICCLH 796_ TMLSL 801_ LSKMK 806_ VAIDE 811_ TWDSQ 816_ SVSPW 821_ WQQMR 826_ TACIQ 831_ SENNG 836_ AALLS 841_ AHVGH 846_ SVAAQ 851_ ISNNM 856_ TEKKF 861_ SQTVL 866_ GADSE 871_ ALTDS 876_ WEALS 881_ LDTEY 886_ WKLLL 891_ KQLED 896_ CLILQ 901_ TLLHS 906_ KGNTQ 911_ TSKVS 916_ SLQAE 921_ PLPRL 926_ SVKKL 931_ LEGGK 936_ GGIAD 941_ SVAKW 946_ IFKQD 951_ FSPEV 956_ LKLAN 961_ EERDA 966_ ENPDE 971_ PKEGV 976_ NRSFL 981_ EVSEM 986_ EMDLG 991_ AIPDL 996_ LHLAY 1001_ EQFPC 1006_ SLELD 1011_ VLHAH 1016_ CCWEY 1021_ VVQWN 1026_ KDPEE 1031_ ARFFV 1036_ RSIEH 1041_ LKQIF 1046_ NAHVQ 1051_ NGIAL 1056_ MMWNT 1061_ FLVKR 1066_ FSAAT 1071_ YLMDK 1076_ VGKSP 1081_ KDRLC 1086_ RRDVG 1091_ MSDTA 1096_ MTSFL 1101_ GSCLD 1106_ LLQIL 1111_ MEADV 1116_ SRDEI 1121_ QVPVL 1126_ DTEDA 1131_ WLSVE 1136_ GPISI 1141_ VELAL 1146_ EQKHI 1151_ HYPLV 1156_ EHHSI 1161_ LCSIL 1166_ YAVMR 1171_ FSLKT 1176_ VKPLS 1181_ LFDSK 1186_ GKNAF 1191_ FKDLT 1196_ SIQLL 1201_ PSGEM 1206_ DPNFI 1211_ SVRQQ 1216_ FLLKV 1221_ VSAAV 1226_ QAQHS 1231_ ATKVK 1236_ DPTEE 1241_ ATPTP 1246_ FGKDQ 1251_ DWPAL 1256_ AVDLA 1261_ HHLQV 1266_ SEDVV 1271_ RRHYV 1276_ GELYN 1281_ YGVDH 1286_ LGEEA 1291_ ILQVH 1296_ DKEVL 1301_ ASQLL 1306_ VLTGQ 1311_ RLAHA 1316_ LLHTQ 1321_ TKEGM 1326_ ELLAR 1331_ LPPTL 1336_ CTWLK 1341_ AMDPQ 1346_ DLQNT 1351_ EVPIA 1356_ TTAKL 1361_ VNKVI 1366_ ELLPE 1371_ KHGQY 1376_ GLALH 1381_ LIEAV 1386_EAISL
1: Regulatory subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of RAB3GAP1 and RAB3GAP2, which has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43, and guanine nucleotide exchange factor (GEF) activity towards RAB18 (PubMed:24891604, PubMed:9733780). As part of the Rab3GAP complex, acts as a GAP for Rab3 proteins by converting active RAB3-GTP to the inactive form RAB3-GDP (By similarity). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones (By similarity). The Rab3GAP complex acts as a GEF for RAB18 by promoting the conversion of inactive RAB18-GDP to the active form RAB18-GTP (PubMed:24891604). Recruits and stabilizes RAB18 at the cis-Golgi membrane in human fibroblasts where RAB18 is most likely activated (PubMed:26063829). Also involved in RAB18 recruitment at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure (PubMed:24891604). Required for normal eye and brain development (By similarity). May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (By similarity)