Gene name: DPH5

Uniprot entry:

Q9H2P9

Protein names:

Diphthine methyl ester synthase (EC 2.1.1.314) (Diphthamide biosynthesis methyltransferase)

Protein sequence:

1_MLYLI 6_ GLGLG 11_ DAKDI 16_ TVKGL 21_ EVVRR 26_ CSRVY 31_ LEAYT 36_ SVLTV 41_ GKEAL 46_ EEFYG 51_ RKLVV 56_ ADREE 61_ VEQEA 66_ DNILK 71_ DADIS 76_ DVAFL 81_ VVGDP 86_ FGATT 91_ HSDLV 96_ LRATK 101_ LGIPY 106_ RVIHN 111_ ASIMN 116_ AVGCC 121_ GLQLY 126_ KFGET 131_ VSIVF 136_ WTDTW 141_ RPESF 146_ FDKVK 151_ KNRQN 156_ GMHTL 161_ CLLDI 166_ KVKEQ 171_ SLENL 176_ IKGRK 181_ IYEPP 186_ RYMSV 191_ NQAAQ 196_ QLLEI 201_ VQNQR 206_ IRGEE 211_ PAVTE 216_ ETLCV 221_ GLARV 226_ GADDQ 231_ KIAAG 236_ TLRQM 241_ CTVDL 246_ GEPLH 251_ SLIIT 256_ GGSIH 261_ PMEME 266_ MLSLF 271_ SIPEN 276_SSESQ

Protein annotations

Protein functions:

1: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis