RING finger protein 39 (Protein HZFw)
1_MWWRD 6_ LTRLR 11_ LWLKR 16_ EAIPG 21_ EGRKA 26_ AKVNA 31_ GVGEK 36_ GIYTA 41_ SSRGG 46_ PPSAR 51_ SKAVT 56_ VVAEG 61_ AASRS 66_ WLSMD 71_ APELG 76_ PGLVE 81_ RLEQL 86_ ATCPL 91_ CGGSF 96_ EDPVL 101_ LACEH 106_ SFCRA 111_ CLARR 116_ WGTPP 121_ ATGTE 126_ ASPTA 131_ CPCCG 136_ LPCPR 141_ RSLRS 146_ NVRLA 151_ VEVRI 156_ SRELR 161_ EKLAE 166_ PGARA 171_ GRRRG 176_ GRIPT 181_ MGCLD 186_ LPGED 191_ MRKTW 196_ RRFEV 201_ PTSKS 206_ SNSED 211_ DLPED 216_ YPVVK 221_ KMLHR 226_ LTADL 231_ TLDPG 236_ TAHRR 241_ LLISA 246_ DRRSV 251_ QLAPP 256_ GTPAP 261_ PDGPK 266_ RFDQL 271_ PAVLG 276_ AQGFG 281_ AGRHC 286_ WEVET 291_ ADAAS 296_ CRDSS 301_ GEDAD 306_ DEESH 311_ YAVGA 316_ AGESV 321_ QRKGC 326_ VRLCP 331_ AGAVW 336_ AVEGR 341_ GGRLW 346_ ALTAP 351_ EPTLL 356_ GGVEP 361_ PPRRI 366_ RVDLD 371_ WERGR 376_ VAFYD 381_ GRSLD 386_ LLYAF 391_ QAPGP 396_ LGERI 401_ FPLFC 406_ TCDPR 411_APLRI
1: Plays an inhibitory role in anti-RNA viral innate immunity by targeting the adapter DDX3X and promoting its 'Lys-48'-linked polyubiquitination (PubMed:33674311). Alternatively, enhances the cGAS-STING pathway activation by promoting 'Lys-63'-linked ubiquitination of STING1, facilitating the STING1-TBK1 complex formation and STING1 activation (PubMed:39255680)
2: (Microbial infection) Plays a positive role in human immunodeficiency virus (HIV-1) replication