Zinc finger protein Eos (Ikaros family zinc finger protein 4)
1_MHTPP 6_ ALPRR 11_ FQGGG 16_ RVRTP 21_ GSHRQ 26_ GKDNL 31_ ERDPS 36_ GGCVP 41_ DFLPQ 46_ AQDSN 51_ HFIME 56_ SLFCE 61_ SSGDS 66_ SLEKE 71_ FLGAP 76_ VGPSV 81_ STPNS 86_ QHSSP 91_ SRSLS 96_ ANSIK 101_ VEMYS 106_ DEESS 111_ RLLGP 116_ DERLL 121_ EKDDS 126_ VIVED 131_ SLSEP 136_ LGYCD 141_ GSGPE 146_ PHSPG 151_ GIRLP 156_ NGKLK 161_ CDVCG 166_ MVCIG 171_ PNVLM 176_ VHKRS 181_ HTGER 186_ PFHCN 191_ QCGAS 196_ FTQKG 201_ NLLRH 206_ IKLHS 211_ GEKPF 216_ KCPFC 221_ NYACR 226_ RRDAL 231_ TGHLR 236_ THSVS 241_ SPTVG 246_ KPYKC 251_ NYCGR 256_ SYKQQ 261_ STLEE 266_ HKERC 271_ HNYLQ 276_ SLSTE 281_ AQALA 286_ GQPGD 291_ EIRDL 296_ EMVPD 301_ SMLHS 306_ SSERP 311_ TFIDR 316_ LANSL 321_ TKRKR 326_ STPQK 331_ FVGEK 336_ QMRFS 341_ LSDLP 346_ YDVNS 351_ GGYEK 356_ DVELV 361_ AHHSL 366_ EPGFG 371_ SSLAF 376_ VGAEH 381_ LRPLR 386_ LPPTN 391_ CISEL 396_ TPVIS 401_ SVYTQ 406_ MQPLP 411_ GRLEL 416_ PGSRE 421_ AGEGP 426_ EDLAD 431_ GGPLL 436_ YRPRG 441_ PLTDP 446_ GASPS 451_ NGCQD 456_ STDTE 461_ SNHED 466_ RVAGV 471_ VSLPQ 476_ GPPPQ 481_ PPPTI 486_ VVGRH 491_ SPAYA 496_ KEDPK 501_ PQEGL 506_ LRGTP 511_ GPSKE 516_ VLRVV 521_ GESGE 526_ PVKAF 531_ KCEHC 536_ RILFL 541_ DHVMF 546_ TIHMG 551_ CHGFR 556_ DPFEC 561_ NICGY 566_ HSQDR 571_ YEFSS 576_HIVRG
1: DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T-cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1 (By similarity)