ATP-dependent DNA/RNA helicase DHX36 (EC 3.6.4.12) (EC 3.6.4.13) (DEAD/H box polypeptide 36) (DEAH-box protein 36) (G4-resolvase-1) (G4R1) (MLE-like protein 1) (RNA helicase associated with AU-rich element protein)
1_MSYDY 6_ HQNWG 11_ RDGGP 16_ RSSGG 21_ GYGGG 26_ PAGGH 31_ GGNRG 36_ SGGGG 41_ GGGGG 46_ GRGGR 51_ GRHPG 56_ HLKGR 61_ EIGMW 66_ YAKKQ 71_ GQKNK 76_ EAERQ 81_ ERAVV 86_ HMDER 91_ REEQI 96_ VQLLN 101_ SVQAK 106_ NDKES 111_ EAQIS 116_ WFAPE 121_ DHGYG 126_ TEVST 131_ KNTPC 136_ SENKL 141_ DIQEK 146_ KLINQ 151_ EKKMF 156_ RIRNR 161_ SYIDR 166_ DSEYL 171_ LQENE 176_ PDGTL 181_ DQKLL 186_ EDLQK 191_ KKNDL 196_ RYIEM 201_ QHFRE 206_ KLPSY 211_ GMQKE 216_ LVNLI 221_ DNHQV 226_ TVISG 231_ ETGCG 236_ KTTQV 241_ TQFIL 246_ DNYIE 251_ RGKGS 256_ ACRIV 261_ CTQPR 266_ RISAI 271_ SVAER 276_ VAAER 281_ AESCG 286_ SGNST 291_ GYQIR 296_ LQSRL 301_ PRKQG 306_ SILYC 311_ TTGII 316_ LQWLQ 321_ SDPYL 326_ SSVSH 331_ IVLDE 336_ IHERN 341_ LQSDV 346_ LMTVV 351_ KDLLN 356_ FRSDL 361_ KVILM 366_ SATLN 371_ AEKFS 376_ EYFGN 381_ CPMIH 386_ IPGFT 391_ FPVVE 396_ YLLED 401_ VIEKI 406_ RYVPE 411_ QKEHR 416_ SQFKR 421_ GFMQG 426_ HVNRQ 431_ EKEEK 436_ EAIYK 441_ ERWPD 446_ YVREL 451_ RRRYS 456_ ASTVD 461_ VIEMM 466_ EDDKV 471_ DLNLI 476_ VALIR 481_ YIVLE 486_ EEDGA 491_ ILVFL 496_ PGWDN 501_ ISTLH 506_ DLLMS 511_ QVMFK 516_ SDKFL 521_ IIPLH 526_ SLMPT 531_ VNQTQ 536_ VFKRT 541_ PPGVR 546_ KIVIA 551_ TNIAE 556_ TSITI 561_ DDVVY 566_ VIDGG 571_ KIKET 576_ HFDTQ 581_ NNIST 586_ MSAEW 591_ VSKAN 596_ AKQRK 601_ GRAGR 606_ VQPGH 611_ CYHLY 616_ NGLRA 621_ SLLDD 626_ YQLPE 631_ ILRTP 636_ LEELC 641_ LQIKI 646_ LRLGG 651_ IAYFL 656_ SRLMD 661_ PPSNE 666_ AVLLS 671_ IRHLM 676_ ELNAL 681_ DKQEE 686_ LTPLG 691_ VHLAR 696_ LPVEP 701_ HIGKM 706_ ILFGA 711_ LFCCL 716_ DPVLT 721_ IAASL 726_ SFKDP 731_ FVIPL 736_ GKEKI 741_ ADARR 746_ KELAK 751_ DTRSD 756_ HLTVV 761_ NAFEG 766_ WEEAR 771_ RRGFR 776_ YEKDY 781_ CWEYF 786_ LSSNT 791_ LQMLH 796_ NMKGQ 801_ FAEHL 806_ LGAGF 811_ VSSRN 816_ PKDPE 821_ SNINS 826_ DNEKI 831_ IKAVI 836_ CAGLY 841_ PKVAK 846_ IRLNL 851_ GKKRK 856_ MVKVY 861_ TKTDG 866_ LVAVH 871_ PKSVN 876_ VEQTD 881_ FHYNW 886_ LIYHL 891_ KMRTS 896_ SIYLY 901_ DCTEV 906_ SPYCL 911_ LFFGG 916_ DISIQ 921_ KDNDQ 926_ ETIAV 931_ DEWIV 936_ FQSPA 941_ RIAHL 946_ VKELR 951_ KELDI 956_ LLQEK 961_ IESPH 966_ PVDWN 971_ DTKSR 976_ DCAVL 981_ SAIID 986_ LIKTQ 991_ EKATP 996_ RNFPP 1001_RFQDG
1: Multifunctional ATP-dependent helicase that unwinds G-quadruplex (G4) structures (PubMed:16150737, PubMed:18854321, PubMed:20472641, PubMed:21586581). Plays a role in many biological processes such as genomic integrity, gene expression regulations and as a sensor to initiate antiviral responses (PubMed:14731398, PubMed:18279852, PubMed:21993297, PubMed:22238380, PubMed:25579584). G4 structures correspond to helical structures containing guanine tetrads (By similarity). Binds with high affinity to and unwinds G4 structures that are formed in nucleic acids (G4-DNA and G4-RNA) (PubMed:16150737, PubMed:18842585, PubMed:20472641, PubMed:21586581, PubMed:24369427, PubMed:26195789). Plays a role in genomic integrity (PubMed:22238380). Converts the G4-RNA structure present in telomerase RNA template component (TREC) into a double-stranded RNA to promote P1 helix formation that acts as a template boundary ensuring accurate reverse transcription (PubMed:20472641, PubMed:21149580, PubMed:21846770, PubMed:22238380, PubMed:24151078, PubMed:25579584). Plays a role in transcriptional regulation (PubMed:21586581, PubMed:21993297). Resolves G4-DNA structures in promoters of genes, such as YY1, KIT/c-kit and ALPL and positively regulates their expression (PubMed:21993297). Plays a role in post-transcriptional regulation (PubMed:27940037). Unwinds a G4-RNA structure located in the 3'-UTR polyadenylation site of the pre-mRNA TP53 and stimulates TP53 pre-mRNA 3'-end processing in response to ultraviolet (UV)-induced DNA damage (PubMed:27940037). Binds to the precursor-microRNA-134 (pre-miR-134) terminal loop and regulates its transport into the synapto-dendritic compartment (By similarity). Involved in the pre-miR-134-dependent inhibition of target gene expression and the control of dendritic spine size (By similarity). Plays a role in the regulation of cytoplasmic mRNA translation and mRNA stability (PubMed:24369427, PubMed:26489465). Binds to both G4-RNA structures and alternative non-quadruplex-forming sequence within the 3'-UTR of the PITX1 mRNA regulating negatively PITX1 protein expression (PubMed:24369427). Binds to both G4-RNA structure in the 5'-UTR and AU-rich elements (AREs) localized in the 3'-UTR of NKX2-5 mRNA to either stimulate protein translation or induce mRNA decay in an ELAVL1-dependent manner, respectively (PubMed:26489465). Also binds to ARE sequences present in several mRNAs mediating exosome-mediated 3'-5' mRNA degradation (PubMed:14731398, PubMed:18279852). Involved in cytoplasmic urokinase-type plasminogen activator (uPA) mRNA decay (PubMed:14731398). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (By similarity). Required for early embryonic development and hematopoiesis. Involved in the regulation of cardioblast differentiation and proliferation during heart development. Involved in spermatogonia differentiation. May play a role in ossification (By similarity)