Protein spinster homolog 1 (HSpin1) (Spinster-like protein 1)
1_MAGSD 6_ TAPFL 11_ SQADD 16_ PDDGP 21_ VPGTP 26_ GLPGS 31_ TGNPK 36_ SEEPE 41_ VPDQE 46_ GLQRI 51_ TGLSP 56_ GRSAL 61_ IVAVL 66_ CYINL 71_ LNYMD 76_ RFTVA 81_ GVLPD 86_ IEQFF 91_ NIGDS 96_ SSGLI 101_ QTVFI 106_ SSYMV 111_ LAPVF 116_ GYLGD 121_ RYNRK 126_ YLMCG 131_ GIAFW 136_ SLVTL 141_ GSSFI 146_ PGEHF 151_ WLLLL 156_ TRGLV 161_ GVGEA 166_ SYSTI 171_ APTLI 176_ ADLFV 181_ ADQRS 186_ RMLSI 191_ FYFAI 196_ PVGSG 201_ LGYIA 206_ GSKVK 211_ DMAGD 216_ WHWAL 221_ RVTPG 226_ LGVVA 231_ VLLLF 236_ LVVRE 241_ PPRGA 246_ VERHS 251_ DLPPL 256_ NPTSW 261_ WADLR 266_ ALARN 271_ PSFVL 276_ SSLGF 281_ TAVAF 286_ VTGSL 291_ ALWAP 296_ AFLLR 301_ SRVVL 306_ GETPP 311_ CLPGD 316_ SCSSS 321_ DSLIF 326_ GLITC 331_ LTGVL 336_ GVGLG 341_ VEISR 346_ RLRHS 351_ NPRAD 356_ PLVCA 361_ TGLLG 366_ SAPFL 371_ FLSLA 376_ CARGS 381_ IVATY 386_ IFIFI 391_ GETLL 396_ SMNWA 401_ IVADI 406_ LLYVV 411_ IPTRR 416_ STAEA 421_ FQIVL 426_ SHLLG 431_ DAGSP 436_ YLIGL 441_ ISDRL 446_ RRNWP 451_ PSFLS 456_ EFRAL 461_ QFSLM 466_ LCAFV 471_ GALGG 476_ AAFLG 481_ TAIFI 486_ EADRR 491_ RAQLH 496_ VQGLL 501_ HEAGS 506_ TDDRI 511_ VVPQR 516_ GRSTR 521_VPVAS
1: Plays a critical role in the phospholipid salvage pathway from lysosomes to the cytosol (PubMed:36161949, PubMed:37075117). Mediates the rate-limiting, proton-dependent, lysosomal efflux of lysophospholipids, which can then be reacylated by acyltransferases in the endoplasmic reticulum to form phospholipids (PubMed:36161949, PubMed:37075117). Selective for zwitterionic headgroups such as lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), can also transport lysophosphatidylglycerol (LPG), but not other anionic lysophospholipids, sphingosine, nor sphingomyelin (PubMed:36161949). Transports lysophospholipids with saturated, monounsaturated, and polyunsaturated fatty acids, such as 1-hexadecanoyl-sn-glycero-3-phosphocholine, 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine and 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine, respectively (PubMed:36161949, PubMed:37075117). Can also transport lysoplasmalogen (LPC with a fatty alcohol) such as 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine (PubMed:36161949). Lysosomal LPC could function as intracellular signaling messenger (PubMed:37075117). Essential player in lysosomal homeostasis (PubMed:36161949). Crucial for cell survival under conditions of nutrient limitation (PubMed:37075117). May be involved in necrotic or autophagic cell death (PubMed:12815463)