Homeobox protein MIXL1 (Homeodomain protein MIX) (hMix) (MIX1 homeobox-like protein 1) (Mix.1 homeobox-like protein)
1_MATAE 6_ SRALQ 11_ FAEGA 16_ AFPAY 21_ RAPHA 26_ GGALL 31_ PPPSP 36_ AAALL 41_ PAPPA 46_ GPGPA 51_ TFAGF 56_ LGRDP 61_ GPAPP 66_ PPASL 71_ GSPAP 76_ PKGAA 81_ APSAS 86_ QRRKR 91_ TSFSA 96_ EQLQL 101_ LELVF 106_ RRTRY 111_ PDIHL 116_ RERLA 121_ ALTLL 126_ PESRI 131_ QVWFQ 136_ NRRAK 141_ SRRQS 146_ GKSFQ 151_ PLARP 156_ EIILN 161_ HCAPG 166_ TETKC 171_ LKPQL 176_ PLEVD 181_ VNCLP 186_ EPNGV 191_ GGGIS 196_ DSSSQ 201_ GQNFE 206_ TCSPL 211_ SEDIG 216_ SKLDS 221_ WEEHI 226_FSAFG
1: Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator of brachyury expression (By similarity)