Gene name: CLEC4M

Uniprot entry:

Q9H2X3

Protein names:

C-type lectin domain family 4 member M (CD209 antigen-like protein 1) (DC-SIGN-related protein) (DC-SIGNR) (Dendritic cell-specific ICAM-3-grabbing non-integrin 2) (DC-SIGN2) (Liver/lymph node-specific ICAM-3-grabbing non-integrin) (L-SIGN) (CD antigen CD299)

Protein sequence:

1_MSDSK 6_ EPRVQ 11_ QLGLL 16_ EEDPT 21_ TSGIR 26_ LFPRD 31_ FQFQQ 36_ IHGHK 41_ SSTGC 46_ LGHGA 51_ LVLQL 56_ LSFML 61_ LAGVL 66_ VAILV 71_ QVSKV 76_ PSSLS 81_ QEQSE 86_ QDAIY 91_ QNLTQ 96_ LKAAV 101_ GELSE 106_ KSKLQ 111_ EIYQE 116_ LTQLK 121_ AAVGE 126_ LPEKS 131_ KLQEI 136_ YQELT 141_ RLKAA 146_ VGELP 151_ EKSKL 156_ QEIYQ 161_ ELTRL 166_ KAAVG 171_ ELPEK 176_ SKLQE 181_ IYQEL 186_ TRLKA 191_ AVGEL 196_ PEKSK 201_ LQEIY 206_ QELTE 211_ LKAAV 216_ GELPE 221_ KSKLQ 226_ EIYQE 231_ LTQLK 236_ AAVGE 241_ LPDQS 246_ KQQQI 251_ YQELT 256_ DLKTA 261_ FERLC 266_ RHCPK 271_ DWTFF 276_ QGNCY 281_ FMSNS 286_ QRNWH 291_ DSVTA 296_ CQEVR 301_ AQLVV 306_ IKTAE 311_ EQNFL 316_ QLQTS 321_ RSNRF 326_ SWMGL 331_ SDLNQ 336_ EGTWQ 341_ WVDGS 346_ PLSPS 351_ FQRYW 356_ NSGEP 361_ NNSGN 366_ EDCAE 371_ FSGSG 376_ WNDNR 381_ CDVDN 386_ YWICK 391_KPAAC

Protein annotations

Protein functions:

1: Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates

2: (Microbial infection) Acts as an attachment receptor for Ebolavirus

3: (Microbial infection) Acts as an attachment receptor for Hepatitis C virus

4: (Microbial infection) Acts as an attachment receptor for HIV-1

5: (Microbial infection) Acts as an attachment receptor for Human coronavirus 229E

6: (Microbial infection) Acts as an attachment receptor for Human cytomegalovirus/HHV-5

7: (Microbial infection) Acts as an attachment receptor for Influenzavirus

8: (Microbial infection) Acts as an attachment receptor for SARS-CoV

9: (Microbial infection) Acts as an attachment receptor for West-nile virus

10: (Microbial infection) Acts as an attachment receptor for Japanese encephalitis virus

11: (Microbial infection) Acts as an attachment receptor for Marburg virus glycoprotein

12: (Microbial infection) Recognition of M.bovis by dendritic cells may occur partially via this molecule