Homeodomain-interacting protein kinase 2 (hHIPk2) (EC 2.7.11.1)
1_MAPVY 6_ EGMAS 11_ HVQVF 16_ SPHTL 21_ QSSAF 26_ CSVKK 31_ LKIEP 36_ SSNWD 41_ MTGYG 46_ SHSKV 51_ YSQSK 56_ NIPLS 61_ QPATT 66_ TVSTS 71_ LPVPN 76_ PSLPY 81_ EQTIV 86_ FPGST 91_ GHIVV 96_ TSASS 101_ TSVTG 106_ QVLGG 111_ PHNLM 116_ RRSTV 121_ SLLDT 126_ YQKCG 131_ LKRKS 136_ EEIEN 141_ TSSVQ 146_ IIEEH 151_ PPMIQ 156_ NNASG 161_ ATVAT 166_ ATTST 171_ ATSKN 176_ SGSNS 181_ EGDYQ 186_ LVQHE 191_ VLCSM 196_ TNTYE 201_ VLEFL 206_ GRGTF 211_ GQVVK 216_ CWKRG 221_ TNEIV 226_ AIKIL 231_ KNHPS 236_ YARQG 241_ QIEVS 246_ ILARL 251_ STESA 256_ DDYNF 261_ VRAYE 266_ CFQHK 271_ NHTCL 276_ VFEML 281_ EQNLY 286_ DFLKQ 291_ NKFSP 296_ LPLKY 301_ IRPVL 306_ QQVAT 311_ ALMKL 316_ KSLGL 321_ IHADL 326_ KPENI 331_ MLVDP 336_ SRQPY 341_ RVKVI 346_ DFGSA 351_ SHVSK 356_ AVCST 361_ YLQSR 366_ YYRAP 371_ EIILG 376_ LPFCE 381_ AIDMW 386_ SLGCV 391_ IAELF 396_ LGWPL 401_ YPGAS 406_ EYDQI 411_ RYISQ 416_ TQGLP 421_ AEYLL 426_ SAGTK 431_ TTRFF 436_ NRDTD 441_ SPYPL 446_ WRLKT 451_ PDDHE 456_ AETGI 461_ KSKEA 466_ RKYIF 471_ NCLDD 476_ MAQVN 481_ MTTDL 486_ EGSDM 491_ LVEKA 496_ DRREF 501_ IDLLK 506_ KMLTI 511_ DADKR 516_ ITPIE 521_ TLNHP 526_ FVTMT 531_ HLLDF 536_ PHSTH 541_ VKSCF 546_ QNMEI 551_ CKRRV 556_ NMYDT 561_ VNQSK 566_ TPFIT 571_ HVAPS 576_ TSTNL 581_ TMTFN 586_ NQLTT 591_ VHNQA 596_ PSSTS 601_ ATISL 606_ ANPEV 611_ SILNY 616_ PSTLY 621_ QPSAA 626_ SMAAV 631_ AQRSM 636_ PLQTG 641_ TAQIC 646_ ARPDP 651_ FQQAL 656_ IVCPP 661_ GFQGL 666_ QASPS 671_ KHAGY 676_ SVRME 681_ NAVPI 686_ VTQAP 691_ GAQPL 696_ QIQPG 701_ LLAQQ 706_ AWPSG 711_ TQQIL 716_ LPPAW 721_ QQLTG 726_ VATHT 731_ SVQHA 736_ TVIPE 741_ TMAGT 746_ QQLAD 751_ WRNTH 756_ AHGSH 761_ YNPIM 766_ QQPAL 771_ LTGHV 776_ TLPAA 781_ QPLNV 786_ GVAHV 791_ MRQQP 796_ TSTTS 801_ SRKSK 806_ QHQSS 811_ VRNVS 816_ TCEVS 821_ SSQAI 826_ SSPQR 831_ SKRVK 836_ ENTPP 841_ RCAMV 846_ HSSPA 851_ CSTSV 856_ TCGWG 861_ DVASS 866_ TTRER 871_ QRQTI 876_ VIPDT 881_ PSPTV 886_ SVITI 891_ SSDTD 896_ EEEEQ 901_ KHAPT 906_ STVSK 911_ QRKNV 916_ ISCVT 921_ VHDSP 926_ YSDSS 931_ SNTSP 936_ YSVQQ 941_ RAGHN 946_ NANAF 951_ DTKGS 956_ LENHC 961_ TGNPR 966_ TIIVP 971_ PLKTQ 976_ ASEVL 981_ VECDS 986_ LVPVN 991_ TSHHS 996_ SSYKS 1001_ KSSSN 1006_ VTSTS 1011_ GHSSG 1016_ SSSGA 1021_ ITYRQ 1026_ QRPGP 1031_ HFQQQ 1036_ QPLNL 1041_ SQAQQ 1046_ HITTD 1051_ RTGSH 1056_ RRQQA 1061_ YITPT 1066_ MAQAP 1071_ YSFPH 1076_ NSPSH 1081_ GTVHP 1086_ HLAAA 1091_ AAAAH 1096_ LPTQP 1101_ HLYTY 1106_ TAPAA 1111_ LGSTG 1116_ TVAHL 1121_ VASQG 1126_ SARHT 1131_ VQHTA 1136_ YPASI 1141_ VHQVP 1146_ VSMGP 1151_ RVLPS 1156_ PTIHP 1161_ SQYPA 1166_ QFAHQ 1171_ TYISA 1176_ SPAST 1181_ VYTGY 1186_ PLSPA 1191_KVNQY
1: Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1, ZBTB4 and DAZAP2. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A. Mediates transcriptional activation of TP73. In response to TGFB, cooperates with DAXX to activate JNK. Negative regulator through phosphorylation and subsequent proteasomal degradation of CTNNB1 and the antiapoptotic factor CTBP1. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between MAP3K7/TAK1 and NLK to promote the proteasomal degradation of MYB. Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity. Activates CREB1 and ATF1 transcription factors by phosphorylation in response to genotoxic stress. In response to DNA damage, stabilizes PML by phosphorylation. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. Promotes angiogenesis, and is involved in erythroid differentiation, especially during fetal liver erythropoiesis. Phosphorylation of RUNX1 and EP300 stimulates EP300 transcription regulation activity. Triggers ZBTB4 protein degradation in response to DNA damage. In response to DNA damage, phosphorylates DAZAP2 which localizes DAZAP2 to the nucleus, reduces interaction of DAZAP2 with HIPK2 and prevents DAZAP2-dependent ubiquitination of HIPK2 by E3 ubiquitin-protein ligase SIAH1 and subsequent proteasomal degradation (PubMed:33591310). Modulates HMGA1 DNA-binding affinity. In response to high glucose, triggers phosphorylation-mediated subnuclear localization shifting of PDX1. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis