Solute carrier family 12 member 5 (Electroneutral potassium-chloride cotransporter 2) (K-Cl cotransporter 2) (hKCC2) (Neuronal K-Cl cotransporter)
1_MSRRF 6_ TVTSL 11_ PPAGP 16_ ARSPD 21_ PESRR 26_ HSVAD 31_ PRHLP 36_ GEDVK 41_ GDGNP 46_ KESSP 51_ FINST 56_ DTEKG 61_ KEYDG 66_ KNMAL 71_ FEEEM 76_ DTSPM 81_ VSSLL 86_ SGLAN 91_ YTNLP 96_ QGSRE 101_ HEEAE 106_ NNEGG 111_ KKKPV 116_ QAPRM 121_ GTFMG 126_ VYLPC 131_ LQNIF 136_ GVILF 141_ LRLTW 146_ VVGIA 151_ GIMES 156_ FCMVF 161_ ICCSC 166_ TMLTA 171_ ISMSA 176_ IATNG 181_ VVPAG 186_ GSYYM 191_ ISRSL 196_ GPEFG 201_ GAVGL 206_ CFYLG 211_ TTFAG 216_ AMYIL 221_ GTIEI 226_ LLAYL 231_ FPAMA 236_ IFKAE 241_ DASGE 246_ AAAML 251_ NNMRV 256_ YGTCV 261_ LTCMA 266_ TVVFV 271_ GVKYV 276_ NKFAL 281_ VFLGC 286_ VILSI 291_ LAIYA 296_ GVIKS 301_ AFDPP 306_ NFPIC 311_ LLGNR 316_ TLSRH 321_ GFDVC 326_ AKLAW 331_ EGNET 336_ VTTRL 341_ WGLFC 346_ SSRFL 351_ NATCD 356_ EYFTR 361_ NNVTE 366_ IQGIP 371_ GAASG 376_ LIKEN 381_ LWSSY 386_ LTKGV 391_ IVERS 396_ GMTSV 401_ GLADG 406_ TPIDM 411_ DHPYV 416_ FSDMT 421_ SYFTL 426_ LVGIY 431_ FPSVT 436_ GIMAG 441_ SNRSG 446_ DLRDA 451_ QKSIP 456_ TGTIL 461_ AIATT 466_ SAVYI 471_ SSVVL 476_ FGACI 481_ EGVVL 486_ RDKFG 491_ EAVNG 496_ NLVVG 501_ TLAWP 506_ SPWVI 511_ VIGSF 516_ FSTCG 521_ AGLQS 526_ LTGAP 531_ RLLQA 536_ ISRDG 541_ IVPFL 546_ QVFGH 551_ GKANG 556_ EPTWA 561_ LLLTA 566_ CICEI 571_ GILIA 576_ SLDEV 581_ APILS 586_ MFFLM 591_ CYMFV 596_ NLACA 601_ VQTLL 606_ RTPNW 611_ RPRFR 616_ YYHWT 621_ LSFLG 626_ MSLCL 631_ ALMFI 636_ CSWYY 641_ ALVAM 646_ LIAGL 651_ IYKYI 656_ EYRGA 661_ EKEWG 666_ DGIRG 671_ LSLSA 676_ ARYAL 681_ LRLEE 686_ GPPHT 691_ KNWRP 696_ QLLVL 701_ VRVDQ 706_ DQNVV 711_ HPQLL 716_ SLTSQ 721_ LKAGK 726_ GLTIV 731_ GSVLE 736_ GTFLE 741_ NHPQA 746_ QRAEE 751_ SIRRL 756_ MEAEK 761_ VKGFC 766_ QVVIS 771_ SNLRD 776_ GVSHL 781_ IQSGG 786_ LGGLQ 791_ HNTVL 796_ VGWPR 801_ NWRQK 806_ EDHQT 811_ WRNFI 816_ ELVRE 821_ TTAGH 826_ LALLV 831_ TKNVS 836_ MFPGN 841_ PERFS 846_ EGSID 851_ VWWIV 856_ HDGGM 861_ LMLLP 866_ FLLRH 871_ HKVWR 876_ KCKMR 881_ IFTVA 886_ QMDDN 891_ SIQMK 896_ KDLTT 901_ FLYHL 906_ RITAE 911_ VEVVE 916_ MHESD 921_ ISAYT 926_ YEKTL 931_ VMEQR 936_ SQILK 941_ QMHLT 946_ KNERE 951_ REIQS 956_ ITDES 961_ RGSIR 966_ RKNPA 971_ NTRLR 976_ LNVPE 981_ ETAGD 986_ SEEKP 991_ EEEVQ 996_ LIHDQ 1001_ SAPSC 1006_ PSSSP 1011_ SPGEE 1016_ PEGEG 1021_ ETDPE 1026_ KVHLT 1031_ WTKDK 1036_ SVAEK 1041_ NKGPS 1046_ PVSSE 1051_ GIKDF 1056_ FSMKP 1061_ EWENL 1066_ NQSNV 1071_ RRMHT 1076_ AVRLN 1081_ EVIVK 1086_ KSRDA 1091_ KLVLL 1096_ NMPGP 1101_ PRNRN 1106_ GDENY 1111_ MEFLE 1116_ VLTEH 1121_ LDRVM 1126_ LVRGG 1131_GREVI
1: Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis (PubMed:12106695). As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition (By similarity). Involved in the regulation of dendritic spine formation and maturation (PubMed:24668262)