Forkhead box protein P1 (Mac-1-regulated forkhead) (MFH)
1_MMQES 6_ GTETK 11_ SNGSA 16_ IQNGS 21_ GGSNH 26_ LLECG 31_ GLREG 36_ RSNGE 41_ TPAVD 46_ IGAAD 51_ LAHAQ 56_ QQQQQ 61_ ALQVA 66_ RQLLL 71_ QQQQQ 76_ QQVSG 81_ LKSPK 86_ RNDKQ 91_ PALQV 96_ PVSVA 101_ MMTPQ 106_ VITPQ 111_ QMQQI 116_ LQQQV 121_ LSPQQ 126_ LQVLL 131_ QQQQA 136_ LMLQQ 141_ QQLQE 146_ FYKKQ 151_ QEQLQ 156_ LQLLQ 161_ QQHAG 166_ KQPKE 171_ QQQVA 176_ TQQLA 181_ FQQQL 186_ LQMQQ 191_ LQQQH 196_ LLSLQ 201_ RQGLL 206_ TIQPG 211_ QPALP 216_ LQPLA 221_ QGMIP 226_ TELQQ 231_ LWKEV 236_ TSAHT 241_ AEETT 246_ GNNHS 251_ SLDLT 256_ TTCVS 261_ SSAPS 266_ KTSLI 271_ MNPHA 276_ STNGQ 281_ LSVHT 286_ PKRES 291_ LSHEE 296_ HPHSH 301_ PLYGH 306_ GVCKW 311_ PGCEA 316_ VCEDF 321_ QSFLK 326_ HLNSE 331_ HALDD 336_ RSTAQ 341_ CRVQM 346_ QVVQQ 351_ LELQL 356_ AKDKE 361_ RLQAM 366_ MTHLH 371_ VKSTE 376_ PKAAP 381_ QPLNL 386_ VSSVT 391_ LSKSA 396_ SEASP 401_ QSLPH 406_ TPTTP 411_ TAPLT 416_ PVTQG 421_ PSVIT 426_ TTSMH 431_ TVGPI 436_ RRRYS 441_ DKYNV 446_ PISSA 451_ DIAQN 456_ QEFYK 461_ NAEVR 466_ PPFTY 471_ ASLIR 476_ QAILE 481_ SPEKQ 486_ LTLNE 491_ IYNWF 496_ TRMFA 501_ YFRRN 506_ AATWK 511_ NAVRH 516_ NLSLH 521_ KCFVR 526_ VENVK 531_ GAVWT 536_ VDEVE 541_ FQKRR 546_ PQKIS 551_ GNPSL 556_ IKNMQ 561_ SSHAY 566_ CTPLN 571_ AALQA 576_ SMAEN 581_ SIPLY 586_ TTASM 591_ GNPTL 596_ GNLAS 601_ AIREE 606_ LNGAM 611_ EHTNS 616_ NESDS 621_ SPGRS 626_ PMQAV 631_ HPVHV 636_ KEEPL 641_ DPEEA 646_ EGPLS 651_ LVTTA 656_ NHSPD 661_ FDHDR 666_ DYEDE 671_PVNED
1: Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal cord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198). Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18347093, PubMed:18799727). Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716). Can negatively regulate androgen receptor signaling (PubMed:18640093). Acts as a transcriptional activator of the FBXL7 promoter; this activity is regulated by AURKA (PubMed:28218735)
2: Involved in transcriptional regulation in embryonic stem cells (ESCs). Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes. Has distinct DNA-binding specifities as compared to the canonical form and preferentially binds DNA with the sequence 5'-CGATACAA-3' (or closely related sequences) (PubMed:21924763). Promotes ESC self-renewal and pluripotency (By similarity)