Tumor protein 63 (p63) (Chronic ulcerative stomatitis protein) (CUSP) (Keratinocyte transcription factor KET) (Transformation-related protein 63) (TP63) (Tumor protein p73-like) (p73L) (p40) (p51)
1_MNFET 6_ SRCAT 11_ LQYCP 16_ DPYIQ 21_ RFVET 26_ PAHFS 31_ WKESY 36_ YRSTM 41_ SQSTQ 46_ TNEFL 51_ SPEVF 56_ QHIWD 61_ FLEQP 66_ ICSVQ 71_ PIDLN 76_ FVDEP 81_ SEDGA 86_ TNKIE 91_ ISMDC 96_ IRMQD 101_ SDLSD 106_ PMWPQ 111_ YTNLG 116_ LLNSM 121_ DQQIQ 126_ NGSSS 131_ TSPYN 136_ TDHAQ 141_ NSVTA 146_ PSPYA 151_ QPSST 156_ FDALS 161_ PSPAI 166_ PSNTD 171_ YPGPH 176_ SFDVS 181_ FQQSS 186_ TAKSA 191_ TWTYS 196_ TELKK 201_ LYCQI 206_ AKTCP 211_ IQIKV 216_ MTPPP 221_ QGAVI 226_ RAMPV 231_ YKKAE 236_ HVTEV 241_ VKRCP 246_ NHELS 251_ REFNE 256_ GQIAP 261_ PSHLI 266_ RVEGN 271_ SHAQY 276_ VEDPI 281_ TGRQS 286_ VLVPY 291_ EPPQV 296_ GTEFT 301_ TVLYN 306_ FMCNS 311_ SCVGG 316_ MNRRP 321_ ILIIV 326_ TLETR 331_ DGQVL 336_ GRRCF 341_ EARIC 346_ ACPGR 351_ DRKAD 356_ EDSIR 361_ KQQVS 366_ DSTKN 371_ GDGTK 376_ RPFRQ 381_ NTHGI 386_ QMTSI 391_ KKRRS 396_ PDDEL 401_ LYLPV 406_ RGRET 411_ YEMLL 416_ KIKES 421_ LELMQ 426_ YLPQH 431_ TIETY 436_ RQQQQ 441_ QQHQH 446_ LLQKQ 451_ TSIQS 456_ PSSYG 461_ NSSPP 466_ LNKMN 471_ SMNKL 476_ PSVSQ 481_ LINPQ 486_ QRNAL 491_ TPTTI 496_ PDGMG 501_ ANIPM 506_ MGTHM 511_ PMAGD 516_ MNGLS 521_ PTQAL 526_ PPPLS 531_ MPSTS 536_ HCTPP 541_ PPYPT 546_ DCSIV 551_ SFLAR 556_ LGCSS 561_ CLDYF 566_ TTQGL 571_ TTIYQ 576_ IEHYS 581_ MDDLA 586_ SLKIP 591_ EQFRH 596_ AIWKG 601_ ILDHR 606_ QLHEF 611_ SSPSH 616_ LLRTP 621_ SSAST 626_ VSVGS 631_ SETRG 636_ ERVID 641_ AVRFT 646_ LRQTI 651_ SFPPR 656_ DEWND 661_ FNFDM 666_ DARRN 671_KQQRI
1: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter