Gene name: MTRFR

Uniprot entry:

Q9H3J6

Protein names:

Mitochondrial translation release factor in rescue

Protein sequence:

1_MSTVG 6_ LFHFP 11_ TPLTR 16_ ICPAP 21_ WGLRL 26_ WEKLT 31_ LLSPG 36_ IAVTP 41_ VQMAG 46_ KKDYP 51_ ALLSL 56_ DENEL 61_ EEQFV 66_ KGHGP 71_ GGQAT 76_ NKTSN 81_ CVVLK 86_ HIPSG 91_ IVVKC 96_ HQTRS 101_ VDQNR 106_ KLARK 111_ ILQEK 116_ VDVFY 121_ NGENS 126_ PVHKE 131_ KREAA 136_ KKKQE 141_ RKKRA 146_ KETLE 151_ KKKLL 156_ KELWE 161_SSKKV

Protein annotations

Protein functions:

1: Part of a mitoribosome-associated quality control pathway that prevents aberrant translation by responding to interruptions during elongation (PubMed:33243891). As heterodimer with MTRES1, ejects the unfinished nascent chain and peptidyl transfer RNA (tRNA), respectively, from stalled ribosomes. Recruitment of mitoribosome biogenesis factors to these quality control intermediates suggests additional roles for MTRES1 and MTRF during mitoribosome rescue (PubMed:33243891)