Growth hormone-inducible transmembrane protein (Dermal papilla-derived protein 2) (Mitochondrial morphology and cristae structure 1) (MICS1) (Transmembrane BAX inhibitor motif-containing protein 5)
1_MLAAR 6_ LVCLR 11_ TLPSR 16_ VFHPA 21_ FTKAS 26_ PVVKN 31_ SITKN 36_ QWLLT 41_ PSREY 46_ ATKTR 51_ IGIRR 56_ GRTGQ 61_ ELKEA 66_ ALEPS 71_ MEKIF 76_ KIDQM 81_ GRWFV 86_ AGGAA 91_ VGLGA 96_ LCYYG 101_ LGLSN 106_ EIGAI 111_ EKAVI 116_ WPQYV 121_ KDRIH 126_ STYMY 131_ LAGSI 136_ GLTAL 141_ SAIAI 146_ SRTPV 151_ LMNFM 156_ MRGSW 161_ VTIGV 166_ TFAAM 171_ VGAGM 176_ LVRSI 181_ PYDQS 186_ PGPKH 191_ LAWLL 196_ HSGVM 201_ GAVVA 206_ PLTIL 211_ GGPLL 216_ IRAAW 221_ YTAGI 226_ VGGLS 231_ TVAMC 236_ APSEK 241_ FLNMG 246_ APLGV 251_ GLGLV 256_ FVSSL 261_ GSMFL 266_ PPTTV 271_ AGATL 276_ YSVAM 281_ YGGLV 286_ LFSMF 291_ LLYDT 296_ QKVIK 301_ RAEVS 306_ PMYGV 311_ QKYDP 316_ INSML 321_ SIYMD 326_ TLNIF 331_ MRVAT 336_MLATG
1: Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport (PubMed:18417609, PubMed:32977469, PubMed:35912435, PubMed:36321428). Mediates proton-dependent calcium efflux from mitochondrion (PubMed:35912435, PubMed:36321428). Also functions as an electroneutral mitochondrial proton/potassium exchanger (PubMed:36321428). Required for the mitochondrial tubular network and cristae organization (PubMed:18417609, PubMed:32977469, PubMed:36321428). Involved in apoptotic release of cytochrome c (PubMed:18417609). Inhibits the proteolytic activity of AFG3L2, stimulating respiration and stabilizing respiratory enzymes in actively respiring mitochondria (PubMed:36321428). However, when mitochondria become hyperpolarized, GHITM loses its inhibitory activity toward AFG3L2 and the now the active AFG3L2 turns first on GHITM and, if hyperpolarization persists, on other proteins of the mitochondria, leading to a broad remodeling of the mitochondrial proteome (PubMed:36321428)