Cobalamin trafficking protein CblD (CblD) (Methylmalonic aciduria and homocystinuria type D protein, mitochondrial)
1_MANVL 6_ CNRAR 11_ LVSYL 16_ PGFCS 21_ LVKRV 26_ VNPKA 31_ FSTAG 36_ SSGSD 41_ ESHVA 46_ AAPPD 51_ ICSRT 56_ VWPDE 61_ TMGPF 66_ GPQDQ 71_ RFQLP 76_ GNIGF 81_ DCHLN 86_ GTASQ 91_ KKSLV 96_ HKTLP 101_ DVLAE 106_ PLSSE 111_ RHEFV 116_ MAQYV 121_ NEFQG 126_ NDAPV 131_ EQEIN 136_ SAETY 141_ FESAR 146_ VECAI 151_ QTCPE 156_ LLRKD 161_ FESLF 166_ PEVAN 171_ GKLMI 176_ LTVTQ 181_ KTKND 186_ MTVWS 191_ EEVEI 196_ EREVL 201_ LEKFI 206_ NGAKE 211_ ICYAL 216_ RAEGY 221_ WADFI 226_ DPSSG 231_ LAFFG 236_ PYTNN 241_ TLFET 246_ DERYR 251_ HLGFS 256_ VDDLG 261_ CCKVI 266_ RHSLW 271_ GTHVV 276_ VGSIF 281_ TNATP 286_ DSHIM 291_KKLSG
1: Involved in cobalamin metabolism and trafficking (PubMed:18385497, PubMed:23415655, PubMed:24722857, PubMed:26364851). Plays a role in regulating the biosynthesis and the proportion of two coenzymes, methylcob(III)alamin (MeCbl) and 5'-deoxyadenosylcobalamin (AdoCbl) (PubMed:18385497, PubMed:23415655, PubMed:24722857). Promotes oxidation of cob(II)alamin bound to MMACHC (PubMed:26364851). The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (PubMed:27771510)