Potassium voltage-gated channel subfamily F member 1 (Voltage-gated potassium channel subunit Kv5.1) (kH1)
1_MDGSG 6_ ERSLP 11_ EPGSQ 16_ SSAAS 21_ DDIEI 26_ VVNVG 31_ GVRQV 36_ LYGDL 41_ LSQYP 46_ ETRLA 51_ ELINC 56_ LAGGY 61_ DTIFS 66_ LCDDY 71_ DPGKR 76_ EFYFD 81_ RDPDA 86_ FKCVI 91_ EVYYF 96_ GEVHM 101_ KKGIC 106_ PICFK 111_ NEMDF 116_ WKVDL 121_ KFLDD 126_ CCKSH 131_ LSEKR 136_ EELEE 141_ IARRV 146_ QLILD 151_ DLGVD 156_ AAEGR 161_ WRRCQ 166_ KCVWK 171_ FLEKP 176_ ESSCP 181_ ARVVA 186_ VLSFL 191_ LILVS 196_ SVVMC 201_ MGTIP 206_ ELQVL 211_ DAEGN 216_ RVEHP 221_ TLENV 226_ ETACI 231_ GWFTL 236_ EYLLR 241_ LFSSP 246_ NKLHF 251_ ALSFM 256_ NIVDV 261_ LAILP 266_ FYVSL 271_ TLTHL 276_ GARMM 281_ ELTNV 286_ QQAVQ 291_ ALRIM 296_ RIARI 301_ FKLAR 306_ HSSGL 311_ QTLTY 316_ ALKRS 321_ FKELG 326_ LLLMY 331_ LAVGI 336_ FVFSA 341_ LGYTM 346_ EQSHP 351_ ETLFK 356_ SIPQS 361_ FWWAI 366_ ITMTT 371_ VGYGD 376_ IYPKT 381_ TLGKL 386_ NAAIS 391_ FLCGV 396_ IAIAL 401_ PIHPI 406_ INNFV 411_ RYYNK 416_ QRVLE 421_ TAAKH 426_ ELELM 431_ ELNSS 436_ SGGEG 441_ KTGGS 446_ RSDLD 451_ NLPPE 456_ PAGKE 461_ APSCS 466_ SRLKL 471_ SHSDT 476_ FIPLL 481_ TEEKH 486_HRTRL
1: Regulatory alpha-subunit of the voltage-gated potassium (Kv) channel which, when coassembled with KCNB1 or KCNB2, can modulate their expression and their gating kinetics by acting on deactivation upon repolarization and inactivation during maintained depolarization. Accelerates inactivation but has relatively little effect on deactivation. Coexpression with KCNB1 or KCNB2 markedly slows inactivation. Each modulatory subunit has its own specific properties of regulation, and can lead to extensive inhibitions, to large changes in kinetics, and/or to large shifts in the voltage dependencies of the inactivation process. The gating kinetics depends on the nature and stoichiometry of the associated regulatory sunbunit. Fails to produce a potassium current when expressed alone