Thioredoxin-interacting protein (Thioredoxin-binding protein 2) (Vitamin D3 up-regulated protein 1)
1_MVMFK 6_ KIKSF 11_ EVVFN 16_ DPEKV 21_ YGSGE 26_ KVAGR 31_ VIVEV 36_ CEVTR 41_ VKAVR 46_ ILACG 51_ VAKVL 56_ WMQGS 61_ QQCKQ 66_ TSEYL 71_ RYEDT 76_ LLLED 81_ QPTGE 86_ NEMVI 91_ MRPGN 96_ KYEYK 101_ FGFEL 106_ PQGPL 111_ GTSFK 116_ GKYGC 121_ VDYWV 126_ KAFLD 131_ RPSQP 136_ TQETK 141_ KNFEV 146_ VDLVD 151_ VNTPD 156_ LMAPV 161_ SAKKE 166_ KKVSC 171_ MFIPD 176_ GRVSV 181_ SARID 186_ RKGFC 191_ EGDEI 196_ SIHAD 201_ FENTC 206_ SRIVV 211_ PKAAI 216_ VARHT 221_ YLANG 226_ QTKVL 231_ TQKLS 236_ SVRGN 241_ HIISG 246_ TCASW 251_ RGKSL 256_ RVQKI 261_ RPSIL 266_ GCNIL 271_ RVEYS 276_ LLIYV 281_ SVPGS 286_ KKVIL 291_ DLPLV 296_ IGSRS 301_ GLSSR 306_ TSSMA 311_ SRTSS 316_ EMSWV 321_ DLNIP 326_ DTPEA 331_ PPCYM 336_ DVIPE 341_ DHRLE 346_ SPTTP 351_ LLDDM 356_ DGSQD 361_ SPIFM 366_ YAPEF 371_ KFMPP 376_ PTYTE 381_ VDPCI 386_LNNNV
1: May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability (PubMed:17603038). Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest (PubMed:12821938). Required for the maturation of natural killer cells (By similarity). Acts as a suppressor of tumor cell growth (PubMed:18541147). Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (PubMed:21460850)