Ataxin-3-like protein (EC 3.4.19.12) (Machado-Joseph disease protein 1-like)
1_MDFIF 6_ HEKQE 11_ GFLCA 16_ QHCLN 21_ NLLQG 26_ EYFSP 31_ VELAS 36_ IAHQL 41_ DEEER 46_ MRMAE 51_ GGVTS 56_ EEYLA 61_ FLQQP 66_ SENMD 71_ DTGFF 76_ SIQVI 81_ SNALK 86_ FWGLE 91_ IIHFN 96_ NPEYQ 101_ KLGID 106_ PINER 111_ SFICN 116_ YKQHW 121_ FTIRK 126_ FGKHW 131_ FNLNS 136_ LLAGP 141_ ELISD 146_ TCLAN 151_ FLARL 156_ QQQAY 161_ SVFVV 166_ KGDLP 171_ DCEAD 176_ QLLQI 181_ ISVEE 186_ MDTPK 191_ LNGKK 196_ LVKQK 201_ EHRVY 206_ KTVLE 211_ KVSEE 216_ SDESG 221_ TSDQD 226_ EEDFQ 231_ RALEL 236_ SRQET 241_ NREDE 246_ HLRST 251_ IELSM 256_ QGSSG 261_ NTSQD 266_ LPKTS 271_ CVTPA 276_ SEQPK 281_ KIKED 286_ YFEKH 291_ QQEQK 296_ QQQQQ 301_ SDLPG 306_ HSSYL 311_ HERPT 316_ TSSRA 321_ IESDL 326_ SDDIS 331_ EGTVQ 336_ AAVDT 341_ ILEIM 346_RKNLK
1: Deubiquitinating enzyme that cleaves both 'Lys-48'-linked and 'Lys-63'-linked poly-ubiquitin chains (in vitro) (PubMed:21118805). Acts as a deubiquitinating enzyme for the transcription factor KLF5, playing a role in the regulation of KLF5 stability (PubMed:26079537)