Thioredoxin-related transmembrane protein 1 (Thioredoxin domain-containing protein 1) (Transmembrane Trx-related protein)
1_MAPSG 6_ SLAVP 11_ LAVLV 16_ LLLWG 21_ APWTH 26_ GRRSN 31_ VRVIT 36_ DENWR 41_ ELLEG 46_ DWMIE 51_ FYAPW 56_ CPACQ 61_ NLQPE 66_ WESFA 71_ EWGED 76_ LEVNI 81_ AKVDV 86_ TEQPG 91_ LSGRF 96_ IITAL 101_ PTIYH 106_ CKDGE 111_ FRRYQ 116_ GPRTK 121_ KDFIN 126_ FISDK 131_ EWKSI 136_ EPVSS 141_ WFGPG 146_ SVLMS 151_ SMSAL 156_ FQLSM 161_ WIRTC 166_ HNYFI 171_ EDLGL 176_ PVWGS 181_ YTVFA 186_ LATLF 191_ SGLLL 196_ GLCMI 201_ FVADC 206_ LCPSK 211_ RRRPQ 216_ PYPYP 221_ SKKLL 226_ SESAQ 231_ PLKKV 236_ EEEQE 241_ ADEED 246_ VSEEE 251_ AESKE 256_ GTNKD 261_ FPQNA 266_ IRQRS 271_LGPSL
1: Thiredoxin domain-containing protein that participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions (PubMed:11152479, PubMed:37648867). Acts as a key inhibitor of the alternative triglyceride biosynthesis pathway by inhibiting the activity of TMEM68/DIESL at the endoplasmic reticulum, thereby restricting accumulation of triacylglycerol (PubMed:37648867). The alternative triglyceride biosynthesis pathway mediates formation of triacylglycerol from diacylglycerol and membrane phospholipids (PubMed:37648867). Acts as a protein disulfide isomerase by catalyzing formation or reduction of disulfide bonds (PubMed:22228764, PubMed:29932915). Specifically mediates formation of disulfide bonds of transmembrane proteins at the endoplasmic reticulum membrane (PubMed:22228764). Involved in endoplasmic reticulum-associated degradation (ERAD) via its protein disulfide isomerase activity by acting on folding-defective polypeptides at the endoplasmic reticulum membrane (PubMed:29932915). Acts as a negative regulator of platelet aggregation following secretion in the extracellular space (PubMed:30425049). Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals (PubMed:27502484, PubMed:31304984). Regulates endoplasmic reticulum-mitochondria Ca(2+) flux (PubMed:27502484)