Lysine-specific demethylase 4C (EC 1.14.11.66) (Gene amplified in squamous cell carcinoma 1 protein) (GASC-1 protein) (JmjC domain-containing histone demethylation protein 3C) (Jumonji domain-containing protein 2C) ([histone H3]-trimethyl-L-lysine(9) demethylase 4C)
1_MEVAE 6_ VESPL 11_ NPSCK 16_ IMTFR 21_ PSMEE 26_ FREFN 31_ KYLAY 36_ MESKG 41_ AHRAG 46_ LAKVI 51_ PPKEW 56_ KPRQC 61_ YDDID 66_ NLLIP 71_ APIQQ 76_ MVTGQ 81_ SGLFT 86_ QYNIQ 91_ KKAMT 96_ VKEFR 101_ QLANS 106_ GKYCT 111_ PRYLD 116_ YEDLE 121_ RKYWK 126_ NLTFV 131_ APIYG 136_ ADING 141_ SIYDE 146_ GVDEW 151_ NIARL 156_ NTVLD 161_ VVEEE 166_ CGISI 171_ EGVNT 176_ PYLYF 181_ GMWKT 186_ TFAWH 191_ TEDMD 196_ LYSIN 201_ YLHFG 206_ EPKSW 211_ YAIPP 216_ EHGKR 221_ LERLA 226_ QGFFP 231_ SSSQG 236_ CDAFL 241_ RHKMT 246_ LISPS 251_ VLKKY 256_ GIPFD 261_ KITQE 266_ AGEFM 271_ ITFPY 276_ GYHAG 281_ FNHGF 286_ NCAES 291_ TNFAT 296_ VRWID 301_ YGKVA 306_ KLCTC 311_ RKDMV 316_ KISMD 321_ IFVRK 326_ FQPDR 331_ YQLWK 336_ QGKDI 341_ YTIDH 346_ TKPTP 351_ ASTPE 356_ VKAWL 361_ QRRRK 366_ VRKAS 371_ RSFQC 376_ ARSTS 381_ KRPKA 386_ DEEEE 391_ VSDEV 396_ DGAEV 401_ PNPDS 406_ VTDDL 411_ KVSEK 416_ SEAAV 421_ KLRNT 426_ EASSE 431_ EESSA 436_ SRMQV 441_ EQNLS 446_ DHIKL 451_ SGNSC 456_ LSTSV 461_ TEDIK 466_ TEDDK 471_ AYAYR 476_ SVPSI 481_ SSEAD 486_ DSIPL 491_ SSGYE 496_ KPEKS 501_ DPSEL 506_ SWPKS 511_ PESCS 516_ SVAES 521_ NGVLT 526_ EGEES 531_ DVESH 536_ GNGLE 541_ PGEIP 546_ AVPSG 551_ ERNSF 556_ KVPSI 561_ AEGEN 566_ KTSKS 571_ WRHPL 576_ SRPPA 581_ RSPMT 586_ LVKQQ 591_ APSDE 596_ ELPEV 601_ LSIEE 606_ EVEET 611_ ESWAK 616_ PLIHL 621_ WQTKS 626_ PNFAA 631_ EQEYN 636_ ATVAR 641_ MKPHC 646_ AICTL 651_ LMPYH 656_ KPDSS 661_ NEEND 666_ ARWET 671_ KLDEV 676_ VTSEG 681_ KTKPL 686_ IPEMC 691_ FIYSE 696_ ENIEY 701_ SPPNA 706_ FLEED 711_ GTSLL 716_ ISCAK 721_ CCVRV 726_ HASCY 731_ GIPSH 736_ EICDG 741_ WLCAR 746_ CKRNA 751_ WTAEC 756_ CLCNL 761_ RGGAL 766_ KQTKN 771_ NKWAH 776_ VMCAV 781_ AVPEV 786_ RFTNV 791_ PERTQ 796_ IDVGR 801_ IPLQR 806_ LKLKC 811_ IFCRH 816_ RVKRV 821_ SGACI 826_ QCSYG 831_ RCPAS 836_ FHVTC 841_ AHAAG 846_ VLMEP 851_ DDWPY 856_ VVNIT 861_ CFRHK 866_ VNPNV 871_ KSKAC 876_ EKVIS 881_ VGQTV 886_ ITKHR 891_ NTRYY 896_ SCRVM 901_ AVTSQ 906_ TFYEV 911_ MFDDG 916_ SFSRD 921_ TFPED 926_ IVSRD 931_ CLKLG 936_ PPAEG 941_ EVVQV 946_ KWPDG 951_ KLYGA 956_ KYFGS 961_ NIAHM 966_ YQVEF 971_ EDGSQ 976_ IAMKR 981_ EDIYT 986_ LDEEL 991_ PKRVK 996_ ARFST 1001_ ASDMR 1006_ FEDTF 1011_ YGADI 1016_ IQGER 1021_ KRQRV 1026_ LSSRF 1031_ KNEYV 1036_ ADPVY 1041_ RTFLK 1046_ SSFQK 1051_KCQKR
1: Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate