Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4 (EC 2.8.2.8) (Glucosaminyl N-deacetylase/N-sulfotransferase 4) (NDST-4) (N-heparan sulfate sulfotransferase 4) (N-HSST 4) [Includes: Heparan sulfate N-deacetylase 4 (EC 3.-.-.-); Heparan sulfate N-sulfotransferase 4 (EC 2.8.2.-)]
1_MNLIV 6_ KLRRS 11_ FRTLI 16_ VLLAT 21_ FCLVS 26_ IVISA 31_ YFLYS 36_ GYKQE 41_ MTLIE 46_ TTAEA 51_ ECTDI 56_ KILPY 61_ RSMEL 66_ KTVKP 71_ IDTSK 76_ TDPTV 81_ LLFVE 86_ SQYSQ 91_ LGQDI 96_ IAILE 101_ SSRFQ 106_ YHMVI 111_ APGKG 116_ DIPPL 121_ TDNGK 126_ GKYTL 131_ VIYEN 136_ ILKYV 141_ SMDSW 146_ NRELL 151_ EKYCV 156_ EYSVS 161_ IIGFH 166_ KANEN 171_ SLPST 176_ QLKGF 181_ PLNLF 186_ NNLAL 191_ KDCFV 196_ NPQSP 201_ LLHIT 206_ KAPKV 211_ EKGPL 216_ PGEDW 221_ TIFQY 226_ NHSTY 231_ QPVLL 236_ TELQT 241_ EKSLS 246_ SLSSK 251_ TLFAT 256_ VIQDL 261_ GLHDG 266_ IQRVL 271_ FGNNL 276_ NFWLH 281_ KLIFI 286_ DAISF 291_ LSGKR 296_ LTLSL 301_ DRYIL 306_ VDIDD 311_ IFVGK 316_ EGTRM 321_ NVKDV 326_ KALLE 331_ TQNLL 336_ RTQVA 341_ NFTFN 346_ LGFSG 351_ KFYHT 356_ GTEEE 361_ DEGDD 366_ LLLRS 371_ VDEFW 376_ WFPHM 381_ WSHMQ 386_ PHLFH 391_ NESSL 396_ VEQMI 401_ LNKEF 406_ ALEHG 411_ IPINM 416_ GYAVA 421_ PHHSG 426_ VYPVH 431_ IQLYA 436_ AWKKV 441_ WGIQV 446_ TSTEE 451_ YPHLK 456_ PARYR 461_ KGFIH 466_ NSIMV 471_ LPRQT 476_ CGLFT 481_ HTIFY 486_ KEYPG 491_ GPQEL 496_ DKSIR 501_ GGELF 506_ LTILL 511_ NPISI 516_ FMTHL 521_ SNYGN 526_ DRLGL 531_ YTFVN 536_ LVNFV 541_ QSWTN 546_ LKLQT 551_ LPPVQ 556_ LAHQY 561_ FELFP 566_ EQKDP 571_ LWQNP 576_ CDDKR 581_ HKDIW 586_ SREKT 591_ CDHLP 596_ KFLVI 601_ GPQKT 606_ GTTAL 611_ YLFLL 616_ MHPSI 621_ ISNLP 626_ SPKTF 631_ EEVQF 636_ FNGNN 641_ YHKGI 646_ DWYMD 651_ FFPTP 656_ SNTTS 661_ DFLFE 666_ KSANY 671_ FHSEE 676_ APRRA 681_ ASLVP 686_ KAKII 691_ TILID 696_ PSDRA 701_ YSWYQ 706_ HQRSH 711_ EDPAA 716_ LRFNF 721_ YEVIS 726_ TGHWA 731_ PSDLK 736_ TLQRR 741_ CLVPG 746_ WYAVH 751_ IERWL 756_ TYFAT 761_ SQLLI 766_ IDGQQ 771_ LRSDP 776_ ATVMD 781_ EVQKF 786_ LGVTP 791_ RYNYS 796_ EALTF 801_ DPQKG 806_ FWCQL 811_ LEGGK 816_ TKCLG 821_ KSKGR 826_ KYPPM 831_ DPESR 836_ TFLSN 841_ YYRDH 846_ NVELS 851_ KLLHR 856_ LGQPL 861_ PSWLR 866_QELQK
1: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity (By similarity)