Thiamin pyrophosphokinase 1 (hTPK1) (EC 2.7.6.2) (Placental protein 20) (PP20) (Thiamine pyrophosphokinase 1)
1_MEHAF 6_ TPLEP 11_ LLSTG 16_ NLKYC 21_ LVILN 26_ QPLDN 31_ YFRHL 36_ WNKAL 41_ LRACA 46_ DGGAN 51_ RLYDI 56_ TEGER 61_ ESFLP 66_ EFING 71_ DFDSI 76_ RPEVR 81_ EYYAT 86_ KGCEL 91_ ISTPD 96_ QDHTD 101_ FTKCL 106_ KMLQK 111_ KIEEK 116_ DLKVD 121_ VIVTL 126_ GGLAG 131_ RFDQI 136_ MASVN 141_ TLFQA 146_ THITP 151_ FPIII 156_ IQEES 161_ LIYLL 166_ QPGKH 171_ RLHVD 176_ TGMEG 181_ DWCGL 186_ IPVGQ 191_ PCMQV 196_ TTTGL 201_ KWNLT 206_ NDVLA 211_ FGTLV 216_ STSNT 221_ YDGSG 226_ VVTVE 231_ TDHPL 236_LWTMA
1: Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate (TPP) utilizing UTP and therefore links the biosynthesis of TPP to pyrimidines metabolism (PubMed:38547260). By producing thiamine pyrophosphate, a cofactor of the mitochondrial pyruvate dehydrogenase indirectly regulates pyruvate oxidation and lipogenesis (PubMed:38547260). Although it can also catalyze thiamine phosphorylation using ATP and CTP in vitro, it does so with significantly lower efficiency and without physiological relevance evidence (PubMed:11342111, PubMed:38547260)