Lck-interacting transmembrane adapter 1 (Lck-interacting membrane protein) (Lck-interacting molecule)
1_MGLPV 6_ SWAPP 11_ ALWVL 16_ GCCAL 21_ LLSLW 26_ ALCTA 31_ CRRPE 36_ DAVAP 41_ RKRAR 46_ RQRAR 51_ LQGSA 56_ TAAEA 61_ SLLRR 66_ THLCS 71_ LSKSD 76_ TRLHE 81_ LHRGP 86_ RSSRA 91_ LRPAS 96_ MDLLR 101_ PHWLE 106_ VSRDI 111_ TGPQA 116_ APSAF 121_ PHQEL 126_ PRALP 131_ AAAAT 136_ AGCAG 141_ LEATY 146_ SNVGL 151_ AALPG 156_ VSLAA 161_ SPVVA 166_ EYARV 171_ QKRKG 176_ THRSP 181_ QEPQQ 186_ GKTEV 191_ TPAAQ 196_ VDVLY 201_ SRVCK 206_ PKRRD 211_ PGPTT 216_ DPLDP 221_ KGQGA 226_ ILALA 231_ GDLAY 236_ QTLPL 241_ RALDV 246_ DSGPL 251_ ENVYE 256_ SIREL 261_ GDPAG 266_ RSSTC 271_ GAGTP 276_ PASSC 281_ PSLGR 286_GWRPL
1: Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T-cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules