Charged multivesicular body protein 4b (Chromatin-modifying protein 4b) (CHMP4b) (SNF7 homolog associated with Alix 1) (SNF7-2) (hSnf7-2) (Vacuolar protein sorting-associated protein 32-2) (Vps32-2) (hVps32-2)
1_MSVFG 6_ KLFGA 11_ GGGKA 16_ GKGGP 21_ TPQEA 26_ IQRLR 31_ DTEEM 36_ LSKKQ 41_ EFLEK 46_ KIEQE 51_ LTAAK 56_ KHGTK 61_ NKRAA 66_ LQALK 71_ RKKRY 76_ EKQLA 81_ QIDGT 86_ LSTIE 91_ FQREA 96_ LENAN 101_ TNTEV 106_ LKNMG 111_ YAAKA 116_ MKAAH 121_ DNMDI 126_ DKVDE 131_ LMQDI 136_ ADQQE 141_ LAEEI 146_ STAIS 151_ KPVGF 156_ GEEFD 161_ EDELM 166_ AELEE 171_ LEQEE 176_ LDKNL 181_ LEISG 186_ PETVP 191_ LPNVP 196_ SIALP 201_ SKPAK 206_ KKEEE 211_ DDDMK 216_ELENW
1: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released (PubMed:12860994, PubMed:18209100). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Plays a role in the endosomal sorting pathway. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4B filaments can promote or stabilize negative curvature and outward budding. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). Majority of the protein exists in a folded closed conformation (PubMed:33349255)
2: (Microbial infection) The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the budding of enveloped viruses (HIV-1 and other lentiviruses). Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release