Frizzled-8 (Fz-8) (hFz8)
1_MEWGY 6_ LLEVT 11_ SLLAA 16_ LALLQ 21_ RSSGA 26_ AAASA 31_ KELAC 36_ QEITV 41_ PLCKG 46_ IGYNY 51_ TYMPN 56_ QFNHD 61_ TQDEA 66_ GLEVH 71_ QFWPL 76_ VEIQC 81_ SPDLK 86_ FFLCS 91_ MYTPI 96_ CLEDY 101_ KKPLP 106_ PCRSV 111_ CERAK 116_ AGCAP 121_ LMRQY 126_ GFAWP 131_ DRMRC 136_ DRLPE 141_ QGNPD 146_ TLCMD 151_ YNRTD 156_ LTTAA 161_ PSPPR 166_ RLPPP 171_ PPGEQ 176_ PPSGS 181_ GHGRP 186_ PGARP 191_ PHRGG 196_ GRGGG 201_ GGDAA 206_ APPAR 211_ GGGGG 216_ GKARP 221_ PGGGA 226_ APCEP 231_ GCQCR 236_ APMVS 241_ VSSER 246_ HPLYN 251_ RVKTG 256_ QIANC 261_ ALPCH 266_ NPFFS 271_ QDERA 276_ FTVFW 281_ IGLWS 286_ VLCFV 291_ STFAT 296_ VSTFL 301_ IDMER 306_ FKYPE 311_ RPIIF 316_ LSACY 321_ LFVSV 326_ GYLVR 331_ LVAGH 336_ EKVAC 341_ SGGAP 346_ GAGGA 351_ GGAGG 356_ AAAGA 361_ GAAGA 366_ GAGGP 371_ GGRGE 376_ YEELG 381_ AVEQH 386_ VRYET 391_ TGPAL 396_ CTVVF 401_ LLVYF 406_ FGMAS 411_ SIWWV 416_ ILSLT 421_ WFLAA 426_ GMKWG 431_ NEAIA 436_ GYSQY 441_ FHLAA 446_ WLVPS 451_ VKSIA 456_ VLALS 461_ SVDGD 466_ PVAGI 471_ CYVGN 476_ QSLDN 481_ LRGFV 486_ LAPLV 491_ IYLFI 496_ GTMFL 501_ LAGFV 506_ SLFRI 511_ RSVIK 516_ QQDGP 521_ TKTHK 526_ LEKLM 531_ IRLGL 536_ FTVLY 541_ TVPAA 546_ VVVAC 551_ LFYEQ 556_ HNRPR 561_ WEATH 566_ NCPCL 571_ RDLQP 576_ DQARR 581_ PDYAV 586_ FMLKY 591_ FMCLV 596_ VGITS 601_ GVWVW 606_ SGKTL 611_ ESWRS 616_ LCTRC 621_ CWASK 626_ GAAVG 631_ GGAGA 636_ TAAGG 641_ GGGPG 646_ GGGGG 651_ GPGGG 656_ GGPGG 661_ GGGSL 666_ YSDVS 671_ TGLTW 676_ RSGTA 681_ SSVSY 686_PKQMP
1: Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1