Gene name: CUEDC2

Uniprot entry:

Q9H467

Protein names:

CUE domain-containing protein 2

Protein sequence:

1_MELER 6_ IVSAA 11_ LLAFV 16_ QTHLP 21_ EADLS 26_ GLDEV 31_ IFSYV 36_ LGVLE 41_ DLGPS 46_ GPSEE 51_ NFDME 56_ AFTEM 61_ MEAYV 66_ PGFAH 71_ IPRGT 76_ IGDMM 81_ QKLSG 86_ QLSDA 91_ RNKEN 96_ LQPQS 101_ SGVQG 106_ QVPIS 111_ PEPLQ 116_ RPEML 121_ KEETR 126_ SSAAA 131_ AADTQ 136_ DEATG 141_ AEEEL 146_ LPGVD 151_ VLLEV 156_ FPTCS 161_ VEQAQ 166_ WVLAK 171_ ARGDL 176_ EEAVQ 181_ MLVEG 186_ KEEGP 191_ AAWEG 196_ PNQDL 201_ PRRLR 206_ GPQKD 211_ ELKSF 216_ ILQKY 221_ MMVDS 226_ AEDQK 231_ IHRPM 236_ APKEA 241_ PKKLI 246_ RYIDN 251_ QVVST 256_ KGERF 261_ KDVRN 266_ PEAEE 271_ MKATY 276_ INLKP 281_ARKYR

Protein annotations

Protein functions:

1: Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism