F-box/LRR-repeat protein 15 (F-box only protein 37)
1_MEPPM 6_ EPSGG 11_ EQEPG 16_ AVRFL 21_ DLPWE 26_ DVLLP 31_ HVLNR 36_ VPLRQ 41_ LLRLQ 46_ RVSRA 51_ FRSLV 56_ QLHLA 61_ GLRRF 66_ DAAQV 71_ GPQIP 76_ RAALA 81_ RLLRD 86_ AEGLQ 91_ ELALA 96_ PCHEW 101_ LSDED 106_ LVPVL 111_ ARNPQ 116_ LRSVA 121_ LGGCG 126_ QLSRR 131_ ALGAL 136_ AEGCP 141_ RLQRL 146_ SLAHC 151_ DWVDG 156_ LALRG 161_ LADRC 166_ PALEE 171_ LDLTA 176_ CRQLK 181_ DEAIV 186_ YLAQR 191_ RGAGL 196_ RSLSL 201_ AVNAN 206_ VGDAA 211_ VQELA 216_ RNCPE 221_ LHHLD 226_ LTGCL 231_ RVGSD 236_ GVRTL 241_ AEYCP 246_ VLRSL 251_ RVRHC 256_ HHVAE 261_ SSLSR 266_ LRKRG 271_ VDIDV 276_ EPPLH 281_ QALVL 286_ LQDMA 291_GFAPF
1: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2