Fructosamine-3-kinase (EC 2.7.1.171) (Protein-psicosamine 3-kinase FN3K) (Protein-ribulosamine 3-kinase FN3K) (EC 2.7.1.172)
1_MEQLL 6_ RAELR 11_ TATLR 16_ AFGGP 21_ GAGCI 26_ SEGRA 31_ YDTDA 36_ GPVFV 41_ KVNRR 46_ TQARQ 51_ MFEGE 56_ VASLE 61_ ALRST 66_ GLVRV 71_ PRPMK 76_ VIDLP 81_ GGGAA 86_ FVMEH 91_ LKMKS 96_ LSSQA 101_ SKLGE 106_ QMADL 111_ HLYNQ 116_ KLREK 121_ LKEEE 126_ NTVGR 131_ RGEGA 136_ EPQYV 141_ DKFGF 146_ HTVTC 151_ CGFIP 156_ QVNEW 161_ QDDWP 166_ TFFAR 171_ HRLQA 176_ QLDLI 181_ EKDYA 186_ DREAR 191_ ELWSR 196_ LQVKI 201_ PDLFC 206_ GLEIV 211_ PALLH 216_ GDLWS 221_ GNVAE 226_ DDVGP 231_ IIYDP 236_ ASFYG 241_ HSEFE 246_ LAIAL 251_ MFGGF 256_ PRSFF 261_ TAYHR 266_ KIPKA 271_ PGFDQ 276_ RLLLY 281_ QLFNY 286_ LNHWN 291_ HFGRE 296_ YRSPS 301_LGTMR
1: Fructosamine-3-kinase involved in protein deglycation by mediating phosphorylation of fructoselysine residues on glycated proteins, to generate fructoselysine-3 phosphate (PubMed:11016445, PubMed:11522682, PubMed:11975663). Fructoselysine-3 phosphate adducts are unstable and decompose under physiological conditions (PubMed:11522682, PubMed:11975663). Involved in intracellular deglycation in erythrocytes (PubMed:11975663). Involved in the response to oxidative stress by mediating deglycation of NFE2L2/NRF2, glycation impairing NFE2L2/NRF2 function (By similarity). Also able to phosphorylate psicosamines and ribulosamines (PubMed:14633848)