Gene name: PIGU

Uniprot entry:

Q9H490

Protein names:

Phosphatidylinositol glycan anchor biosynthesis class U protein (Cell division cycle protein 91-like 1) (Protein CDC91-like 1) (GPI transamidase component PIG-U)

Protein sequence:

1_MAAPL 6_ VLVLV 11_ VAVTV 16_ RAALF 21_ RSSLA 26_ EFISE 31_ RVEVV 36_ SPLSS 41_ WKRVV 46_ EGLSL 51_ LDLGV 56_ SPYSG 61_ AVFHE 66_ TPLII 71_ YLFHF 76_ LIDYA 81_ ELVFM 86_ ITDAL 91_ TAIAL 96_ YFAIQ 101_ DFNKV 106_ VFKKQ 111_ KLLLE 116_ LDQYA 121_ PDVAE 126_ LIRTP 131_ MEMRY 136_ IPLKV 141_ ALFYL 146_ LNPYT 151_ ILSCV 156_ AKSTC 161_ AINNT 166_ LIAFF 171_ ILTTI 176_ KGSAF 181_ LSAIF 186_ LALAT 191_ YQSLY 196_ PLTLF 201_ VPGLL 206_ YLLQR 211_ QYIPV 216_ KMKSK 221_ AFWIF 226_ SWEYA 231_ MMYVG 236_ SLVVI 241_ ICLSF 246_ FLLSS 251_ WDFIP 256_ AVYGF 261_ ILSVP 266_ DLTPN 271_ IGLFW 276_ YFFAE 281_ MFEHF 286_ SLFFV 291_ CVFQI 296_ NVFFY 301_ TIPLA 306_ IKLKE 311_ HPIFF 316_ MFIQI 321_ AVIAI 326_ FKSYP 331_ TVGDV 336_ ALYMA 341_ FFPVW 346_ NHLYR 351_ FLRNI 356_ FVLTC 361_ IIIVC 366_ SLLFP 371_ VLWHL 376_ WIYAG 381_ SANSN 386_ FFYAI 391_ TLTFN 396_ VGQIL 401_ LISDY 406_ FYAFL 411_ RREYY 416_ LTHGL 421_ YLTAK 426_DGTEA

Protein annotations

Protein functions:

1: Component of the glycosylphosphatidylinositol-anchor (GPI-anchor) transamidase (GPI-T) complex that catalyzes the formation of the linkage between a proprotein and a GPI-anchor and participates in GPI anchored protein biosynthesis (PubMed:12802054, PubMed:31353022, PubMed:34576938, PubMed:35165458, PubMed:35551457, PubMed:37684232). Binds the lipid portion of GPI-anchor (PubMed:37684232). May act as an organizer in the transmembrane layer to recruit other subunits, and thus is essential for assembly of the complex (PubMed:35165458, PubMed:35551457)