Microtubule-associated proteins 1A/1B light chain 3A (Autophagy-related protein LC3 A) (Autophagy-related ubiquitin-like modifier LC3 A) (MAP1 light chain 3-like protein 1) (MAP1A/MAP1B light chain 3 A) (MAP1A/MAP1B LC3 A) (Microtubule-associated protein 1 light chain 3 alpha)
1_MPSDR 6_ PFKQR 11_ RSFAD 16_ RCKEV 21_ QQIRD 26_ QHPSK 31_ IPVII 36_ ERYKG 41_ EKQLP 46_ VLDKT 51_ KFLVP 56_ DHVNM 61_ SELVK 66_ IIRRR 71_ LQLNP 76_ TQAFF 81_ LLVNQ 86_ HSMVS 91_ VSTPI 96_ ADIYE 101_ QEKDE 106_ DGFLY 111_ MVYAS 116_QETFG
1: Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes) (PubMed:20713600, PubMed:24290141). While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20713600). Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006537, PubMed:31006538)