Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Cytokine-inducible serine/threonine-protein kinase) (FGF-inducible kinase) (Polo-like kinase 3) (PLK-3) (Proliferation-related kinase)
1_MEPAA 6_ GFLSP 11_ RPFQR 16_ AAAAP 21_ APPAG 26_ PGPPP 31_ SALRG 36_ PELEM 41_ LAGLP 46_ TSDPG 51_ RLITD 56_ PRSGR 61_ TYLKG 66_ RLLGK 71_ GGFAR 76_ CYEAT 81_ DTETG 86_ SAYAV 91_ KVIPQ 96_ SRVAK 101_ PHQRE 106_ KILNE 111_ IELHR 116_ DLQHR 121_ HIVRF 126_ SHHFE 131_ DADNI 136_ YIFLE 141_ LCSRK 146_ SLAHI 151_ WKARH 156_ TLLEP 161_ EVRYY 166_ LRQIL 171_ SGLKY 176_ LHQRG 181_ ILHRD 186_ LKLGN 191_ FFITE 196_ NMELK 201_ VGDFG 206_ LAARL 211_ EPPEQ 216_ RKKTI 221_ CGTPN 226_ YVAPE 231_ VLLRQ 236_ GHGPE 241_ ADVWS 246_ LGCVM 251_ YTLLC 256_ GSPPF 261_ ETADL 266_ KETYR 271_ CIKQV 276_ HYTLP 281_ ASLSL 286_ PARQL 291_ LAAIL 296_ RASPR 301_ DRPSI 306_ DQILR 311_ HDFFT 316_ KGYTP 321_ DRLPI 326_ SSCVT 331_ VPDLT 336_ PPNPA 341_ RSLFA 346_ KVTKS 351_ LFGRK 356_ KKSKN 361_ HAQER 366_ DEVSG 371_ LVSGL 376_ MRTSV 381_ GHQDA 386_ RPEAP 391_ AASGP 396_ APVSL 401_ VETAP 406_ EDSSP 411_ RGTLA 416_ SSGDG 421_ FEEGL 426_ TVATV 431_ VESAL 436_ CALRN 441_ CIAFM 446_ PPAEQ 451_ NPAPL 456_ AQPEP 461_ LVWVS 466_ KWVDY 471_ SNKFG 476_ FGYQL 481_ SSRRV 486_ AVLFN 491_ DGTHM 496_ ALSAN 501_ RKTVH 506_ YNPTS 511_ TKHFS 516_ FSVGA 521_ VPRAL 526_ QPQLG 531_ ILRYF 536_ ASYME 541_ QHLMK 546_ GGDLP 551_ SVEEV 556_ EVPAP 561_ PLLLQ 566_ WVKTD 571_ QALLM 576_ LFSDG 581_ TVQVN 586_ FYGDH 591_ TKLIL 596_ SGWEP 601_ LLVTF 606_ VARNR 611_ SACTY 616_ LASHL 621_ RQLGC 626_ SPDLR 631_ QRLRY 636_ ALRLL 641_RDRSP
1: Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins that are already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Plays a key role in response to stress: rapidly activated upon stress stimulation, such as ionizing radiation, reactive oxygen species (ROS), hyperosmotic stress, UV irradiation and hypoxia. Involved in DNA damage response and G1/S transition checkpoint by phosphorylating CDC25A, p53/TP53 and p73/TP73. Phosphorylates p53/TP53 in response to reactive oxygen species (ROS), thereby promoting p53/TP53-mediated apoptosis. Phosphorylates CHEK2 in response to DNA damage, promoting the G2/M transition checkpoint. Phosphorylates the transcription factor p73/TP73 in response to DNA damage, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates HIF1A and JUN is response to hypoxia. Phosphorylates ATF2 following hyperosmotic stress in corneal epithelium. Also involved in Golgi disassembly during the cell cycle: part of a MEK1/MAP2K1-dependent pathway that induces Golgi fragmentation during mitosis by mediating phosphorylation of VRK1. May participate in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation, via its interaction with CIB1