Dipeptidase 3 (EC 3.4.13.19)
1_MQPTG 6_ REGSR 11_ ALSRR 16_ YLRRL 21_ LLLLL 26_ LLLLR 31_ QPVTR 36_ AETTP 41_ GAPRA 46_ LSTLG 51_ SPSLF 56_ TTPGV 61_ PSALT 66_ TPGLT 71_ TPGTP 76_ KTLDL 81_ RGRAQ 86_ ALMRS 91_ FPLVD 96_ GHNDL 101_ PQVLR 106_ QRYKN 111_ VLQDV 116_ NLRNF 121_ SHGQT 126_ SLDRL 131_ RDGLV 136_ GAQFW 141_ SASVS 146_ CQSQD 151_ QTAVR 156_ LALEQ 161_ IDLIH 166_ RMCAS 171_ YSELE 176_ LVTSA 181_ EGLNS 186_ SQKLA 191_ CLIGV 196_ EGGHS 201_ LDSSL 206_ SVLRS 211_ FYVLG 216_ VRYLT 221_ LTFTC 226_ STPWA 231_ ESSTK 236_ FRHHM 241_ YTNVS 246_ GLTSF 251_ GEKVV 256_ EELNR 261_ LGMMI 266_ DLSYA 271_ SDTLI 276_ RRVLE 281_ VSQAP 286_ VIFSH 291_ SAARA 296_ VCDNL 301_ LNVPD 306_ DILQL 311_ LKKNG 316_ GIVMV 321_ TLSMG 326_ VLQCN 331_ LLANV 336_ STVAD 341_ HFDHI 346_ RAVIG 351_ SEFIG 356_ IGGNY 361_ DGTGR 366_ FPQGL 371_ EDVST 376_ YPVLI 381_ EELLS 386_ RSWSE 391_ EELQG 396_ VLRGN 401_ LLRVF 406_ RQVEK 411_ VREES 416_ RAQSP 421_ VEAEF 426_ PYGQL 431_ STSCH 436_ SHLVP 441_ QNGHQ 446_ ATHLE 451_ VTKQP 456_ TNRVP 461_ WRSSN 466_ ASPYL 471_ VPGLV 476_ AAATI 481_PTFTQ
1: Lacks dipeptidase activity and is unable to hydrolyze cystinyl-bis-glycine, leukotriene D4 and the beta-lactam antibiotic imipenem (PubMed:32325220). The absence of activity may be due to the inability of asparagine (instead of aspartate found in DPEP1/2) at position 359 to function as the acid/base catalyst and activate the nucleophilic water/hydroxide (PubMed:32325220). A tyrosine (instead of histidine) at position 269 reduces affinity for the beta zinc and may cause substrate steric hindrance (PubMed:32325220)