Differentially expressed in FDCP 6 homolog (DEF-6) (IRF4-binding protein)
1_MALRK 6_ ELLKS 11_ IWYAF 16_ TALDV 21_ EKSGK 26_ VSKSQ 31_ LKVLS 36_ HNLYT 41_ VLHIP 46_ HDPVA 51_ LEEHF 56_ RDDDD 61_ GPVSS 66_ QGYMP 71_ YLNKY 76_ ILDKV 81_ EEGAF 86_ VKEHF 91_ DELCW 96_ TLTAK 101_ KNYRA 106_ DSNGN 111_ SMLSN 116_ QDAFR 121_ LWCLF 126_ NFLSE 131_ DKYPL 136_ IMVPD 141_ EVEYL 146_ LKKVL 151_ SSMSL 156_ EVSLG 161_ ELEEL 166_ LAQEA 171_ QVAQT 176_ TGGLS 181_ VWQFL 186_ ELFNS 191_ GRCLR 196_ GVGRD 201_ TLSMA 206_ IHEVY 211_ QELIQ 216_ DVLKQ 221_ GYLWK 226_ RGHLR 231_ RNWAE 236_ RWFQL 241_ QPSCL 246_ CYFGS 251_ EECKE 256_ KRGII 261_ PLDAH 266_ CCVEV 271_ LPDRD 276_ GKRCM 281_ FCVKT 286_ ANRTY 291_ EMSAS 296_ DTRQR 301_ QEWTA 306_ AIQMA 311_ IRLQA 316_ EGKTS 321_ LHKDL 326_ KQKRR 331_ EQREQ 336_ RERRR 341_ AAKEE 346_ ELLRL 351_ QQLQE 356_ EKERK 361_ LQELE 366_ LLQEA 371_ QRQAE 376_ RLLQE 381_ EEERR 386_ RSQHR 391_ ELQQA 396_ LEGQL 401_ REAEQ 406_ ARASM 411_ QAEME 416_ LKEEE 421_ AARQR 426_ QRIKE 431_ LEEMQ 436_ QRLQE 441_ ALQLE 446_ VKARR 451_ DEESV 456_ RIAQT 461_ RLLEE 466_ EEEKL 471_ KQLMQ 476_ LKEEQ 481_ ERYIE 486_ RAQQE 491_ KEELQ 496_ QEMAQ 501_ QSRSL 506_ QQAQQ 511_ QLEEV 516_ RQNRQ 521_ RADED 526_ VEAAQ 531_ RKLRQ 536_ ASTNV 541_ KHWNV 546_ QMNRL 551_ MHPIE 556_ PGDKR 561_ PVTSS 566_ SFSGF 571_ QPPLL 576_ AHRDS 581_ SLKRL 586_ TRWGS 591_ QGNRT 596_ PSPNS 601_ NEQQK 606_ SLNGG 611_ DEAPA 616_ PASTP 621_ QEDKL 626_DPAPE
1: Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42 (PubMed:12651066, PubMed:15023524). Can regulate cell morphology in cooperation with activated RAC1 (By similarity). Involved in immune homeostasis by ensuring proper trafficking and availability of T-cell regulator CTLA-4 at T-cell surface (PubMed:31308374). Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling (By similarity)