Essential MCU regulator, mitochondrial (Single-pass membrane protein with aspartate-rich tail 1, mitochondrial)
1_MASGA 6_ ARWLV 11_ LAPVR 16_ SGALR 21_ SGPSL 26_ RKDGD 31_ VSAAW 36_ SGSGR 41_ SLVPS 46_ RSVIV 51_ TRSGA 56_ ILPKP 61_ VKMSF 66_ GLLRV 71_ FSIVI 76_ PFLYV 81_ GTLIS 86_ KNFAA 91_ LLEEH 96_ DIFVP 101_EDDDD
1: Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria (PubMed:24231807, PubMed:26774479, PubMed:27099988, PubMed:30454562, PubMed:31080062, PubMed:32315830, PubMed:32494073, PubMed:32762847, PubMed:32790952, PubMed:33296646). Required to bridge the calcium-sensing proteins MICU1 with the calcium-conducting subunit MCU (PubMed:24231807, PubMed:30454562, PubMed:32494073, PubMed:32762847, PubMed:32790952). Acts by mediating activation of MCU and retention of MICU1 to the MCU pore, in order to ensure tight regulation of the uniplex complex and appropriate responses to intracellular calcium signaling (PubMed:27099988, PubMed:31080062, PubMed:32315830, PubMed:33296646)