Sentrin-specific protease 3 (EC 3.4.22.-) (SUMO-1-specific protease 3) (Sentrin/SUMO-specific protease SENP3)
1_MKETI 6_ QGTGS 11_ WGPEP 16_ PGPGI 21_ PPAYS 26_ SPRRE 31_ RLRWP 36_ PPPKP 41_ RLKSG 46_ GGFGP 51_ DPGSG 56_ TTVPA 61_ RRLPV 66_ PRPSF 71_ DASAS 76_ EEEEE 81_ EEEEE 86_ DEDEE 91_ EEVAA 96_ WRLPP 101_ RWSQL 106_ GTSQR 111_ PRPSR 116_ PTHRK 121_ TCSQR 126_ RRRAM 131_ RAFRM 136_ LLYSK 141_ STSLT 146_ FHWKL 151_ WGRHR 156_ GRRRG 161_ LAHPK 166_ NHLSP 171_ QQGGA 176_ TPQVP 181_ SPCCR 186_ FDSPR 191_ GPPPP 196_ RLGLL 201_ GALMA 206_ EDGVR 211_ GSPPV 216_ PSGPP 221_ MEEDG 226_ LRWTP 231_ KSPLD 236_ PDSGL 241_ LSCTL 246_ PNGFG 251_ GQSGP 256_ EGERS 261_ LAPPD 266_ ASILI 271_ SNVCS 276_ IGDHV 281_ AQELF 286_ QGSDL 291_ GMAEE 296_ AERPG 301_ EKAGQ 306_ HSPLR 311_ EEHVT 316_ CVQSI 321_ LDEFL 326_ QTYGS 331_ LIPLS 336_ TDEVV 341_ EKLED 346_ IFQQE 351_ FSTPS 356_ RKGLV 361_ LQLIQ 366_ SYQRM 371_ PGNAM 376_ VRGFR 381_ VAYKR 386_ HVLTM 391_ DDLGT 396_ LYGQN 401_ WLNDQ 406_ VMNMY 411_ GDLVM 416_ DTVPE 421_ KVHFF 426_ NSFFY 431_ DKLRT 436_ KGYDG 441_ VKRWT 446_ KNVDI 451_ FNKEL 456_ LLIPI 461_ HLEVH 466_ WSLIS 471_ VDVRR 476_ RTITY 481_ FDSQR 486_ TLNRR 491_ CPKHI 496_ AKYLQ 501_ AEAVK 506_ KDRLD 511_ FHQGW 516_ KGYFK 521_ MNVAR 526_ QNNDS 531_ DCGAF 536_ VLQYC 541_ KHLAL 546_ SQPFS 551_ FTQQD 556_ MPKLR 561_ RQIYK 566_ELCHC
1: Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates (PubMed:16608850, PubMed:32832608, PubMed:36050397). Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability (PubMed:15743823). Deconjugates SUMO2 and SUMO3 from CDCA8 (PubMed:18946085). Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300 (PubMed:19680224). Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1 (PubMed:19015314). Plays a role in the regulation of sumoylation status of ZNF148 (PubMed:18259216). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Deconjugates SUMO2 from KAT5 (PubMed:32832608). Catalyzes desumoylation of MRE11 (PubMed:36050397)