Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3)
1_MMSDE 6_ KNLGV 11_ SQKLV 16_ SPSRS 21_ TSSCS 26_ SKQGS 31_ RQDSW 36_ EVVEG 41_ LRGEM 46_ NYTQE 51_ PPVQK 56_ GFLLK 61_ KRKWP 66_ LKGWH 71_ KRFFY 76_ LDKGI 81_ LKYAK 86_ SQTDI 91_ EREKL 96_ HGCID 101_ VGLSV 106_ MSVKK 111_ SSKCI 116_ DLDTE 121_ EHIYH 126_ LKVKS 131_ EEVFD 136_ EWVSK 141_ LRHHR 146_ MYRQN 151_ EIAMF 156_ PHEVN 161_ HFFSG 166_ STITD 171_ SSSGV 176_ FDSIS 181_ SRKRS 186_ SISKQ 191_ NLFQT 196_ GSNVS 201_ FSCGG 206_ ETRVP 211_ LWLQS 216_ SEDME 221_ KCSKD 226_ LAHCH 231_ AYLVE 236_ MSQLL 241_ QSMDV 246_ LHRTY 251_ SAPAI 256_ NAIQG 261_ GSFES 266_ PKKEK 271_ RSHRR 276_ WRSRA 281_ IGKDA 286_ KGTLQ 291_ VPKPF 296_ SGPVR 301_ LHSSN 306_ PNLST 311_ LDFGE 316_ EKNYS 321_ DGSET 326_ SSEFS 331_ KMQED 336_ LCHIA 341_ HKVYF 346_ TLRSA 351_ FNIMS 356_ AEREK 361_ LKQLM 366_ EQDAS 371_ SSPSA 376_ QVIGL 381_ KNALS 386_ SALAQ 391_ NTDLK 396_ ERLRR 401_ IHAES 406_ LLLDS 411_ PAVAK 416_ SGDNL 421_ AEENS 426_ RDENR 431_ ALVHQ 436_ LSNES 441_ RLSIT 446_ DSLSE 451_ FFDAQ 456_ EVLLS 461_ PSSSE 466_ NEISD 471_ DDSYV 476_ SDISD 481_ NLSLD 486_ NLSND 491_ LDNER 496_ QTLGP 501_ VLDSG 506_ REAKS 511_ RRRTC 516_ LPAPC 521_ PSSSN 526_ ISLWN 531_ ILRNN 536_ IGKDL 541_ SKVAM 546_ PVELN 551_ EPLNT 556_ LQRLC 561_ EELEY 566_ SELLD 571_ KAAQI 576_ PSPLE 581_ RMVYV 586_ AAFAI 591_ SAYAS 596_ SYYRA 601_ GSKPF 606_ NPVLG 611_ ETYEC 616_ IREDK 621_ GFQFF 626_ SEQVS 631_ HHPPI 636_ SACHA 641_ ESRNF 646_ VFWQD 651_ VRWKN 656_ KFWGK 661_ SMEIV 666_ PIGTT 671_ HVTLP 676_ VFGDH 681_ FEWNK 686_ VTSCI 691_ HNILS 696_ GQRWI 701_ EHYGE 706_ IVIKN 711_ LHDDS 716_ CYCKV 721_ NFIKA 726_ KYWST 731_ NAHEI 736_ EGTVF 741_ DRSGK 746_ AVHRL 751_ FGKWH 756_ ESIYC 761_ GGGSS 766_ SACVW 771_ RANPM 776_ PKGYE 781_ QYYSF 786_ TQFAL 791_ ELNEM 796_ DPSSK 801_ SLLPP 806_ TDTRF 811_ RPDQR 816_ FLEEG 821_ NLEEA 826_ EIQKQ 831_ RIEQL 836_ QRERR 841_ RVLEE 846_ NHVEH 851_ QPRFF 856_ RKSDD 861_ DSWVS 866_ NGTYL 871_ ELRKD 876_ LGFSK 881_LDHPV
1: Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193)