SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (EC 3.6.4.12) (ATP-dependent helicase 1) (hHEL1)
1_MNLFN 6_ LDRFR 11_ FEKRN 16_ KIEEA 21_ PEATP 26_ QPSQP 31_ GPSSP 36_ ISLSA 41_ EEENA 46_ EGEVS 51_ RANTP 56_ DSDIT 61_ EKTED 66_ SSVPE 71_ TPDNE 76_ RKASI 81_ SYFKN 86_ QRGIQ 91_ YIDLS 96_ SDSED 101_ VVSPN 106_ CSNTV 111_ QEKTF 116_ NKDTV 121_ IIVSE 126_ PSEDE 131_ ESQGL 136_ PTMAR 141_ RNDDI 146_ SELED 151_ LSELE 156_ DLKDA 161_ KLQTL 166_ KELFP 171_ QRSDN 176_ DLLKL 181_ IESTS 186_ TMDGA 191_ IAAAL 196_ LMFGD 201_ AGGGP 206_ RKRKL 211_ SSSSE 216_ PYEED 221_ EFNDD 226_ QSIKK 231_ TRLDH 236_ GEESN 241_ ESAES 246_ SSNWE 251_ KQESI 256_ VLKLQ 261_ KEFPN 266_ FDKQE 271_ LREVL 276_ KEHEW 281_ MYTEA 286_ LESLK 291_ VFAED 296_ QDMQY 301_ VSQSE 306_ VPNGK 311_ EVSSR 316_ SQNYP 321_ KNATK 326_ TKLKQ 331_ KFSMK 336_ AQNGF 341_ NKKRK 346_ KNVFN 351_ PKRVV 356_ EDSEY 361_ DSGSD 366_ VGSSL 371_ DEDYS 376_ SGEEV 381_ MEDGY 386_ KGKIL 391_ HFLQD 396_ ASIGE 401_ LTLIP 406_ QCSQK 411_ KAQKI 416_ TELRP 421_ FNSWE 426_ ALFTK 431_ MSKTN 436_ GLSED 441_ LIWHC 446_ KTLIQ 451_ ERDVV 456_ IRLMN 461_ KCEDI 466_ SNKLT 471_ KQVTM 476_ LTGNG 481_ GGWNI 486_ EQPSI 491_ LNQSL 496_ SLKPY 501_ QKVGL 506_ NWLAL 511_ VHKHG 516_ LNGIL 521_ ADEMG 526_ LGKTI 531_ QAIAF 536_ LAYLY 541_ QEGNN 546_ GPHLI 551_ VVPAS 556_ TIDNW 561_ LREVN 566_ LWCPT 571_ LKVLC 576_ YYGSQ 581_ EERKQ 586_ IRFNI 591_ HSRYE 596_ DYNVI 601_ VTTYN 606_ CAISS 611_ SDDRS 616_ LFRRL 621_ KLNYA 626_ IFDEG 631_ HMLKN 636_ MGSIR 641_ YQHLM 646_ TINAN 651_ NRLLL 656_ TGTPV 661_ QNNLL 666_ ELMSL 671_ LNFVM 676_ PHMFS 681_ SSTSE 686_ IRRMF 691_ SSKTK 696_ SADEQ 701_ SIYEK 706_ ERIAH 711_ AKQII 716_ KPFIL 721_ RRVKE 726_ EVLKQ 731_ LPPKK 736_ DRIEL 741_ CAMSE 746_ KQEQL 751_ YLGLF 756_ NRLKK 761_ SINNL 766_ EKNTE 771_ MCNVM 776_ MQLRK 781_ MANHP 786_ LLHRQ 791_ YYTAE 796_ KLKEM 801_ SQLML 806_ KEPTH 811_ CEANP 816_ DLIFE 821_ DMEVM 826_ TDFEL 831_ HVLCK 836_ QYRHI 841_ NNFQL 846_ DMDLI 851_ LDSGK 856_ FRVLG 861_ CILSE 866_ LKQKG 871_ DRVVL 876_ FSQFT 881_ MMLDI 886_ LEVLL 891_ KHHQH 896_ RYLRL 901_ DGKTQ 906_ ISERI 911_ HLIDE 916_ FNTDM 921_ DIFVF 926_ LLSTK 931_ AGGLG 936_ INLTS 941_ ANVVI 946_ LHDID 951_ CNPYN 956_ DKQAE 961_ DRCHR 966_ VGQTK 971_ EVLVI 976_ KLISQ 981_ GTIEE 986_ SMLKI 991_ NQQKL 996_ KLEQD 1001_ MTTVD 1006_ EGDEG 1011_ SMPAD 1016_ IATLL 1021_KTSMG
1: DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing