EH domain-containing protein 1 (PAST homolog 1) (hPAST1) (Testilin)
1_MFSWV 6_ SKDAR 11_ RKKEP 16_ ELFQT 21_ VAEGL 26_ RQLYA 31_ QKLLP 36_ LEEHY 41_ RFHEF 46_ HSPAL 51_ EDADF 56_ DNKPM 61_ VLLVG 66_ QYSTG 71_ KTTFI 76_ RHLIE 81_ QDFPG 86_ MRIGP 91_ EPTTD 96_ SFIAV 101_ MHGPT 106_ EGVVP 111_ GNALV 116_ VDPRR 121_ PFRKL 126_ NAFGN 131_ AFLNR 136_ FMCAQ 141_ LPNPV 146_ LDSIS 151_ IIDTP 156_ GILSG 161_ EKQRI 166_ SRGYD 171_ FAAVL 176_ EWFAE 181_ RVDRI 186_ ILLFD 191_ AHKLD 196_ ISDEF 201_ SEVIK 206_ ALKNH 211_ EDKIR 216_ VVLNK 221_ ADQIE 226_ TQQLM 231_ RVYGA 236_ LMWSL 241_ GKIIN 246_ TPEVV 251_ RVYIG 256_ SFWSH 261_ PLLIP 266_ DNRKL 271_ FEAEE 276_ QDLFK 281_ DIQSL 286_ PRNAA 291_ LRKLN 296_ DLIKR 301_ ARLAK 306_ VHAYI 311_ ISSLK 316_ KEMPN 321_ VFGKE 326_ SKKKE 331_ LVNNL 336_ GEIYQ 341_ KIERE 346_ HQISP 351_ GDFPS 356_ LRKMQ 361_ ELLQT 366_ QDFSK 371_ FQALK 376_ PKLLD 381_ TVDDM 386_ LANDI 391_ ARLMV 396_ MVRQE 401_ ESLMP 406_ SQVVK 411_ GGAFD 416_ GTMNG 421_ PFGHG 426_ YGEGA 431_ GEGID 436_ DVEWV 441_ VGKDK 446_ PTYDE 451_ IFYTL 456_ SPVNG 461_ KITGA 466_ NAKKE 471_ MVKSK 476_ LPNTV 481_ LGKIW 486_ KLADV 491_ DKDGL 496_ LDDEE 501_ FALAN 506_ HLIKV 511_ KLEGH 516_ ELPAD 521_ LPPHL 526_VPPSK
1: ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes vesiculation of endocytic membranes (PubMed:24019528). Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes (PubMed:15020713, PubMed:17233914, PubMed:20801876). Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth (By similarity). Plays a role in myoblast fusion (By similarity). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity). Plays a role in the formation of the ciliary vesicle (CV), an early step in cilium biogenesis (PubMed:31615969). Proposed to be required for the fusion of distal appendage vesicles (DAVs) to form the CV by recruiting SNARE complex component SNAP29. Is required for recruitment of transition zone proteins CEP290, RPGRIP1L, TMEM67 and B9D2, and of IFT20 following DAV reorganization before Rab8-dependent ciliary membrane extension. Required for the loss of CCP110 form the mother centriole essential for the maturation of the basal body during ciliogenesis (PubMed:25686250)