E3 ubiquitin-protein ligase NRDP1 (EC 2.3.2.27) (RING finger protein 41) (RING-type E3 ubiquitin transferase NRDP1)
1_MGYDV 6_ TRFQG 11_ DVDED 16_ LICPI 21_ CSGVL 26_ EEPVQ 31_ APHCE 36_ HAFCN 41_ ACITQ 46_ WFSQQ 51_ QTCPV 56_ DRSVV 61_ TVAHL 66_ RPVPR 71_ IMRNM 76_ LSKLQ 81_ IACDN 86_ AVFGC 91_ SAVVR 96_ LDNLM 101_ SHLSD 106_ CEHNP 111_ KRPVT 116_ CEQGC 121_ GLEMP 126_ KDELP 131_ NHNCI 136_ KHLRS 141_ VVQQQ 146_ QTRIA 151_ ELEKT 156_ SAEHK 161_ HQLAE 166_ QKRDI 171_ QLLKA 176_ YMRAI 181_ RSVNP 186_ NLQNL 191_ EETIE 196_ YNEIL 201_ EWVNS 206_ LQPAR 211_ VTRWG 216_ GMIST 221_ PDAVL 226_ QAVIK 231_ RSLVE 236_ SGCPA 241_ SIVNE 246_ LIENA 251_ HERSW 256_ PQGLA 261_ TLETR 266_ QMNRR 271_ YYENY 276_ VAKRI 281_ PGKQA 286_ VVVMA 291_ CENQH 296_ MGDDM 301_ VQEPG 306_ LVMIF 311_AHGVE
1: Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of pro-inflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus (By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Also acts as a PRKN modifier that accelerates its degradation, resulting in a reduction of PRKN activity, influencing the balance of intracellular redox state. The RNF41-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control (PubMed:24949970)