PR domain zinc finger protein 12 (EC 2.1.1.-) (PR domain-containing protein 12)
1_MMGSV 6_ LPAEA 11_ LVLKT 16_ GLKAP 21_ GLALA 26_ EVITS 31_ DILHS 36_ FLYGR 41_ WRNVL 46_ GEQLF 51_ EDKSH 56_ HASPK 61_ TAFTA 66_ EVLAQ 71_ SFSGE 76_ VQKLS 81_ SLVLP 86_ AEVII 91_ AQSSI 96_ PGEGL 101_ GIFSK 106_ TWIKA 111_ GTEMG 116_ PFTGR 121_ VIAPE 126_ HVDIC 131_ KNNNL 136_ MWEVF 141_ NEDGT 146_ VRYFI 151_ DASQE 156_ DHRSW 161_ MTYIK 166_ CARNE 171_ QEQNL 176_ EVVQI 181_ GTSIF 186_ YKAIE 191_ MIPPD 196_ QELLV 201_ WYGNS 206_ HNTFL 211_ GIPGV 216_ PGLEE 221_ DQKKN 226_ KHEDF 231_ HPADS 236_ AAGPA 241_ GRMRC 246_ VICHR 251_ GFNSR 256_ SNLRS 261_ HMRIH 266_ TLDKP 271_ FVCRF 276_ CNRRF 281_ SQSST 286_ LRNHV 291_ RLHTG 296_ ERPYK 301_ CQVCQ 306_ SAYSQ 311_ LAGLR 316_ AHQKS 321_ ARHRP 326_ PSTAL 331_ QAHSP 336_ ALPAP 341_ HAHAP 346_ ALAAA 351_ AAAAA 356_ AAAAH 361_HLPAM
1: Transcriptional regulator necessary for the development of nociceptive neurons, playing a key role in determining the nociceptive lineage from neural crest cell progenitors. Initiates neurogenesis and activates downstream pro-neuronal transcription factors, such as NEUROD1, BRN3A, and ISL1, specifically within nociceptive neurons, while repressing non-nociceptor cell fates. Essential for the proper function of nociceptors in adults, influencing both their excitability and their gene expression, thereby impacting how these neurons respond to various pain stimuli