Histone-lysine N-methyltransferase SUV39H2 (EC 2.1.1.355) (Histone H3-K9 methyltransferase 2) (H3-K9-HMTase 2) (Lysine N-methyltransferase 1B) (Suppressor of variegation 3-9 homolog 2) (Su(var)3-9 homolog 2)
1_MAAVG 6_ AEARG 11_ AWCVP 16_ CLVSL 21_ DTLQE 26_ LCRKE 31_ KLTCK 36_ SIGIT 41_ KRNLN 46_ NYEVE 51_ YLCDY 56_ KVVKD 61_ MEYYL 66_ VKWKG 71_ WPDST 76_ NTWEP 81_ LQNLK 86_ CPLLL 91_ QQFSN 96_ DKHNY 101_ LSQVK 106_ KGKAI 111_ TPKDN 116_ NKTLK 121_ PAIAE 126_ YIVKK 131_ AKQRI 136_ ALQRW 141_ QDELN 146_ RRKNH 151_ KGMIF 156_ VENTV 161_ DLEGP 166_ PSDFY 171_ YINEY 176_ KPAPG 181_ ISLVN 186_ EATFG 191_ CSCTD 196_ CFFQK 201_ CCPAE 206_ AGVLL 211_ AYNKN 216_ QQIKI 221_ PPGTP 226_ IYECN 231_ SRCQC 236_ GPDCP 241_ NRIVQ 246_ KGTQY 251_ SLCIF 256_ RTSNG 261_ RGWGV 266_ KTLVK 271_ IKRMS 276_ FVMEY 281_ VGEVI 286_ TSEEA 291_ ERRGQ 296_ FYDNK 301_ GITYL 306_ FDLDY 311_ ESDEF 316_ TVDAA 321_ RYGNV 326_ SHFVN 331_ HSCDP 336_ NLQVF 341_ NVFID 346_ NLDTR 351_ LPRIA 356_ LFSTR 361_ TINAG 366_ EELTF 371_ DYQMK 376_ GSGDI 381_ SSDSI 386_ DHSPA 391_ KKRVR 396_ TVCKC 401_GAVTC
1: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation